International Chemical Safety Cards 2-NITROANISOLE ICSC: 1520 Benzene, 1-methoxy-2-nitro- 1-Methoxy-2-nitrobenzene o-Nitrophenyl methyl ether o-Nitroanisole NO2C6H4OCH3 / C7H7NO3 Molecular mass: 153.1 ICSC #    1520 CAS #     91-23-6 RTECS # BZ8790000 UN #        2730 EC #         609-047-00-7 April 21, 2004 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Carbon dioxide , foam , powder . EXPLOSION EXPOSURE AVOID ALL CONTACT!  •INHALATION Blue lips or finger nails. Dizziness. Headache. Nausea. Confusion. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Dry skin. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. Personal protection: filter respirator for organic gases and vapours. Chemical protection suit. Well closed. Note: E T symbol R: 45-22 S: 53-45 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 1520 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 2-NITROANISOLE ICSC: 1520 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO YELLOW-RED LIQUID PHYSICAL DANGERS: The vapour is heavier than air. CHEMICAL DANGERS: On combustion, forms toxic and corrosive fumes. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK: Carcinogen category: 2; (DFG 2003). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: A harmful concentration of airborne particles can be reached quickly on spraying. EFFECTS OF SHORT-TERM EXPOSURE: Exposure at high levels may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The liquid defats the skin. This substance is possibly carcinogenic to humans. The substance may have effects on the blood , resulting in anaemia . PHYSICAL PROPERTIES Boiling point: 277°C Melting point: 10°C Relative density (water = 1): 1.25 Solubility in water: at 20 °C none Vapour pressure, kPa at 30°C: 0.004 Relative vapour density (air = 1): 5.29 Flash point: 124°C Auto-ignition temperature: 464°C Explosive limits, vol% in air: 1.04-66 Octanol/water partition coefficient as log Pow: 1.73 ENVIRONMENTAL DATA The substance is harmful to aquatic organisms. N O T E S Do NOT take working clothes home. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Transport Emergency Card: TEC (R)-61GT1-III . ADDITIONAL INFORMATION ICSC: 1520 2-NITROANISOLE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.