The Registry of Toxic Effects of Chemical Substances

Anisole, o - nitro -

RTECS #: BZ8790000

CAS #: 91-23-6

UPDATE: May 2005 MW: 153.15 MF: C7H7NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, 1 - methoxy - 2 - nitro - (9CI)
  2. 2 - Methoxynitrobenzene
  3. 1 - Methoxy - 2 - nitrobenzene
  4. NCI - C60388
  1. o - Nitroanisole
  2. 2 - Nitroanisole
  3. ortho - Nitrobenzene methyl ether
  4. o - Nitrophenyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,060 mg/L EMMUEG 10(Suppl 10),1,1987
DNA repair Bacillus subtilis 500 nL/disc MUREAV 170,11,1986
mutation in microorganisms Salmonella typhimurium 666 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) SAIGBL 29,34,1987
sister chromatid exchange hamster ovary 123 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 173 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-416,1993
oral
mouse 		lowest published toxic dose: 173,040 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTIS** PB94-109758
oral
rat 		lowest published toxic dose: 9,604 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTPTR* NTP-TR-416,1993
oral
rat 		lowest published toxic dose: 28,811.16 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB94-109758
oral
rat 		lowest published toxic dose: 72,100 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB94-109758


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 1,300 mg/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes 		GISAAA 51(1),85,1986
oral
mouse 		lethal dose (50 percent kill): 1,300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		VCVGK* -,291,1994
oral
rat 		lethal dose (50 percent kill): 740 mg/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes 		GISAAA 51(1),85,1986
oral
rat 		lethal dose (50 percent kill): 760 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		VCVGK* -,291,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,772 mg/kg/14 day- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-416,1993
oral
mouse 		lowest published toxic dose: 16,380 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-416,1993
oral
rat 		lowest published toxic dose: 8,960 mg/kg/14 day- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-416,1993
oral
rat 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count 		NTPTR* NTP-TR-416,1993
oral
rat 		lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight 		VCVGK* -,292,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,369,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,369,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,369,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for various pharmaceuticals
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an intermediate for various pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 35973-13-8
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