The Registry of Toxic Effects of Chemical Substances
Anisole, o - nitro - |
UPDATE: May 2005 | MW: 153.15 | MF: C7H7NO3 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 1,060 mg/L | EMMUEG 10(Suppl 10),1,1987 |
DNA repair | Bacillus subtilis | 500 nL/disc | MUREAV 170,11,1986 |
mutation in microorganisms | Salmonella typhimurium | 666 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in microorganisms | Salmonella typhimurium | 1 mg/plate (-enzymatic activation step) | SAIGBL 29,34,1987 |
sister chromatid exchange | hamster ovary | 123 mg/L | EMMUEG 10(Suppl 10),1,1987 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 173 gm/kg/2 year- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTPTR* NTP-TR-416,1993 |
oral mouse | lowest published toxic dose: 173,040 mg/kg/103 week- continuous |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | NTIS** PB94-109758 |
oral rat | lowest published toxic dose: 9,604 mg/kg/2 year- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTPTR* NTP-TR-416,1993 |
oral rat | lowest published toxic dose: 28,811.16 mg/kg/103 week- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTIS** PB94-109758 |
oral rat | lowest published toxic dose: 72,100 mg/kg/103 week- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Blood: Leukemia | NTIS** PB94-109758 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lethal dose (50 percent kill): 1,300 mg/kg |
Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Other changes | GISAAA 51(1),85,1986 |
oral mouse | lethal dose (50 percent kill): 1,300 mg/kg |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair | VCVGK* -,291,1994 |
oral rat | lethal dose (50 percent kill): 740 mg/kg |
Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Other changes | GISAAA 51(1),85,1986 |
oral rat | lethal dose (50 percent kill): 760 mg/kg |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair | VCVGK* -,291,1994 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 2,772 mg/kg/14 day- continuous |
Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-416,1993 |
oral mouse | lowest published toxic dose: 16,380 mg/kg/13 week- continuous |
Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-416,1993 |
oral rat | lowest published toxic dose: 8,960 mg/kg/14 day- continuous |
Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-416,1993 |
oral rat | lowest published toxic dose: 27,300 mg/kg/13 week- continuous |
Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Blood: Changes in erythrocyte (RBC) count | NTPTR* NTP-TR-416,1993 |
oral rat | lowest published toxic dose: 4,500 mg/kg/30 day- intermittent |
Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight | VCVGK* -,292,1994 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Sufficient Evidence | IMEMDT 65,369,1996 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 65,369,1996 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 2B | IMEMDT 65,369,1996 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - GERMANY | Carcinogen, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 1 mg/m3, Skin, JAN1993 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
N/R | N/R | N/R |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an intermediate for various pharmaceuticals | |
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat | |
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen |
REFERENCES: | |
CODEN |
REFERENCE |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |
SAIGBL | Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |