International Chemical Safety Cards TETRACHLOROPHTHALIC ANHYDRIDE ICSC: 1374 4,5,6,7-Tetrachloro-1,3-isobenzofurandione 1,3-Dioxy-4,5,6,7-tetrachloroisobenzofuran C8Cl4O3 / C6Cl4(CO)2O Molecular mass: 285.9 ICSC #    1374 CAS #     117-08-8 RTECS # TI3450000 EC #         607-242-00-1 March 14, 2001 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Water spray, powder. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION Cough. Sore throat. Wheezing. Shortness of breath. Local exhaust or breathing protection. Fresh air, rest. Half-upright position. Refer for medical attention.  •SKIN Redness. Burning sensation. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Redness. Pain. Blurred vision. Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Burning sensation. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.) Dry. Well closed. Xn symbol N symbol R: 41-42/43-50/53 S: 2-22-24-26-37/39-60-61 SEE IMPORTANT INFORMATION ON BACK ICSC: 1374 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards TETRACHLOROPHTHALIC ANHYDRIDE ICSC: 1374 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE POWDER PHYSICAL DANGERS: CHEMICAL DANGERS: Reacts slowly with water to produce acid. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. PHYSICAL PROPERTIES Boiling point: 371°C Melting point: 255°C Solubility in water, g/100 ml at 20°C: 0.4 Flash point: 362°C c.c. ENVIRONMENTAL DATA N O T E S The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. ADDITIONAL INFORMATION ICSC: 1374 TETRACHLOROPHTHALIC ANHYDRIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.