The Registry of Toxic Effects of Chemical Substances

Phthalic anhydride, tetrachloro -

RTECS #: TI3450000

CAS #: 117-08-8

UPDATE: December 2000 MW: 285.88 MF: C8Cl4O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. CP 626
  2. 1,3 - Isobenzofurandione, 4,5,6,7 - tetrachloro - (9CI)
  3. NCI - C61585
  4. Niagathal
  1. 4,5,6,7 - Tetrachloro - 1,3 - isobenzofurandione
  2. Tetrachlorophthalic anhydride
  3. Tetrathal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild NTPTR* NIH-93-3351


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >3,600 mg/m3/4 hour N/R NTPTR* NIH-93-3351
oral
rat 		lethal dose (50 percent kill): >15,800 mg/kg N/R NTPTR* NIH-93-3351
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R NTPTR* NIH-93-3351


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Hyperglycemia

Blood: Changes in leukocyte (WBC) count 		NTIS** OTS0538630
oral
rat 		lowest published toxic dose: 68,250 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NIH-93-3351


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3316;
Number of Industries 2;
Total Number of Facilities 55;
Number of Occupations 3;
Total Number of Employees Exposed 142
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3316;
Number of Industries 4;
Total Number of Facilities 43;
Number of Occupations 6;
Total Number of Employees Exposed 2,067;
Total Number of Female Employees Exposed 786


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a flame retardant in plastics
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8912
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-28, October 2000


REFERENCES:

CODEN
REFERENCE
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a flame retardant in plastics

RTECS Compound Description:
   Tumorigen
   Primary Irritant

 Click Here for Additional Information about RTECS