International Chemical Safety Cards

TETRAHYDROPHTHALIC ANHYDRIDE

ICSC: 1372

4-Cyclohexene-1,2-dicarboxylic anhydride
3a,4,7,7a-Tetrahydro-1,3-isobenzofurandione
THPA
1,2,3,6-Tetrahydrophthalic anhydride
C₈H₈O₃ / C₆H₈(CO)₂O
Molecular mass: 152.2

ICSC #    1372
CAS #     85-43-8
RTECS # GW5775000
UN #        2698
EC #         607-099-00-5
March 14, 2001 Peer reviewed

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Combustible.	NO open flames.	Powder, water spray, foam, carbon dioxide.
EXPLOSION

EXPOSURE		PREVENT DISPERSION OF DUST!
•INHALATION	Cough. Sore throat. Wheezing. Shortness of breath.	Local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Refer for medical attention.
•SKIN	Redness. Burning sensation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
•EYES	Redness. Pain. Blurred vision. Severe deep burns.	Safety goggles, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	Burning sensation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Do NOT induce vomiting.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)

Separated from food and feedstuffs . Dry. Well closed.

Do not transport with food and feedstuffs.
Note: C
Xn symbol
R: 41-42/43-52/53
S: 2-22-24-26-37/39-61
UN Hazard Class: 8
UN Packing Group: III

SEE IMPORTANT INFORMATION ON BACK

ICSC: 1372

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

TETRAHYDROPHTHALIC ANHYDRIDE

ICSC: 1372

I

M

P

O

R

T

A

N

T

D

A

T

A

PHYSICAL STATE; APPEARANCE:
WHITE CRYSTALLINE POWDER

PHYSICAL DANGERS:

CHEMICAL DANGERS:
The substance decomposes on contact with hot surfaces or flames producing corrosive fumes . Reacts with oxidants. Reacts with water to produce heat and tetrahydrophthalic acid.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes , the skin and the respiratory tract.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma.

PHYSICAL
PROPERTIES

Boiling point at 6.7 kPa: 195°C
Melting point: 102°C
Density: 1.4
g/cm3
Solubility in water:
reaction

Vapour pressure, Pa at 20°C: 1
Relative vapour density (air = 1): 5.3
Flash point:
157°C o.c.
Auto-ignition temperature: 450°C

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms.

N O T E S

The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. For cis-isomer the CAS number is 935-79-5.

Transport Emergency Card: TEC (R)-80G09c

ADDITIONAL INFORMATION

ICSC: 1372	TETRAHYDROPHTHALIC ANHYDRIDE
(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.