The Registry of Toxic Effects of Chemical Substances

4 - Cyclohexene - 1,2 - dicarboxylic anhydride

RTECS #: GW5775000

CAS #: 85-43-8

UPDATE: October 1997 MW: 152.16 MF: C8H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Anhydrid kyseliny tetrahydroftalove (Czech)
  2. 1,3 - Isobenzofurandione, 3a,4,7,7a - tetrahydro -
  3. Maleic anhydride adduct of butadiene
  4. Phthalic anhydride, 1,2,3,6 - tetrahydro -
  5. Tetrahydroftalanhydrid (Czech)
  1. Tetrahydrophthalic acid anhydride
  2. Tetrahydrophthalic anhydride
  3. delta (sup 4) - Tetrahydrophthalic anhydride
  4. 1,2,3,6 - Tetrahydrophthalic anhydride
  5. THPA


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,322,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,322,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >294 mg/m3 N/R GTPZAB 29(12),37,1985
inhalation
rat 		lethal concentration : >294 mg/m3 N/R GTPZAB 29(12),37,1985
intraperitoneal
mouse 		lowest published lethal dose: 500 mg/kg N/R CBCCT* 7,780,1955
unreported route
guinea pig 		lethal dose (50 percent kill): 3,500 mg/kg N/R GTPZAB 29(12),37,1985
unreported route
mouse 		lethal dose (50 percent kill): 3,300 mg/kg N/R GTPZAB 29(12),37,1985
unreported route
rat 		lethal dose (50 percent kill): 3 gm/kg N/R GTPZAB 29(12),37,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2931;
Number of Industries 3;
Total Number of Facilities 39;
Number of Occupations 9;
Total Number of Employees Exposed 1,584;
Total Number of Female Employees Exposed 547


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a major feedstock in unsaturated polyester resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI

Used as a major feedstock in unsaturated polyester resins

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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