International Chemical Safety Cards ISONIAZID ICSC: 1258 Isonicotinic hydrazide 4-Pyridinecarboxylic acid, hydrazide C6H7N3O Molecular mass: 137.1 ICSC #    1258 CAS #     54-85-3 RTECS # NS1751850 March 15, 1995 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION Local exhaust or breathing protection. Fresh air, rest.  •SKIN Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.  •EYES Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Confusion. Convulsions. Nausea. Weakness. Ataxia. Hallucinations. Do not eat, drink, or smoke during work. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles). Cool. Well closed. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 1258 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ISONIAZID ICSC: 1258 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE CRYSTALLINE POWDER. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating and on burning producing toxic fumes including nitrogen oxides. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the nervous system and kidneys , resulting in disorientation, lethargy, coma, metabolic acidosis. Exposure at high level could cause death. Exposure may result in unconsciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the central nervous system and the liver , resulting in tissue lesions and impaired functions. PHYSICAL PROPERTIES Melting point: 170-173°C Solubility in water, g/100 ml at 20°C: 12.5 ENVIRONMENTAL DATA N O T E S Many trade names are known for this compound. ADDITIONAL INFORMATION ICSC: 1258 ISONIAZID (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.