The Registry of Toxic Effects of Chemical Substances

Isonicotinic acid hydrazide

RTECS #: NS1751850

CAS #: 54-85-3

UPDATE: May 2005 MW: 137.16 MF: C6H7N3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Andrazide
  2. Antimicina
  3. Antituberkulosum
  4. Armazide
  5. Atcotibine
  6. Azuren
  7. Chemiazid
  8. Chemidon
  9. Cotinazin
  10. Defonin
  11. Niteban
  12. Nydrazid
  13. NSC 9659
  14. Pelazid
  15. Phthisen
  16. Preparation 6424
  17. Pycazide
  18. 4 - Pyridinecarboxylic acid, hydrazide
  19. 4 - Pyridinecarboxylic hydrazide
  20. Pyrizidin
  21. Dibutin
  22. Razide
  23. Raumanon
  24. Rimicid
  25. Rimifon
  26. Rimitsid
  27. Retozide
  28. Rifamate
  29. Robisellin
  30. Roxifen
  31. 5015 RP
  32. Diforin
  33. RU - EF - TB
  34. Sanohidrazina
  35. Sauterazid
  36. Stanozide
  37. TB - Phlogin
  38. TB - Razide
  39. TB - Vis
  40. Tebecid
  41. Tebenic
  42. Tebexin
  43. Dinacrin
  44. Tebilon
  45. Tebos
  46. Teebaconin
  47. Tekazin
  48. Tibazide
  49. Tibinide
  50. Tibison
  51. Tibivis
  52. Tibizide
  53. Tibusan
  54. Ditubin
  55. Tisin
  56. Tisiodrazida
  57. Tizide
  58. Tubomel
  59. Tubazid
  60. Tubazide
  61. Tubeco
  62. Tubercid
  63. Tuberian
  64. Tubicon
  65. Ebidene
  66. Unicozyde
  67. Tyvid
  68. USAF CB - 2
  69. Vazadrine
  70. Vederon
  71. Zinadon
  72. Zonazide
  73. Eralon
  74. Ertuban
  75. Eutizon
  76. Evalon
  77. Fimalene
  78. FSR 3
  1. GInk
  2. HIA
  3. Hidranizil
  4. Hidrasonil
  5. Hidrulta
  6. Hidrun
  7. Hycozid
  8. Hydrazid
  9. 4 - (Hydrazinocarbonyl) pyridine
  10. Hyozid
  11. Hyzyd
  12. I.A.I.
  13. Ido - tebin
  14. Idrazide dell'acido isonicotinico (Italian)
  15. Idrazil
  16. IN - 73
  17. INAH
  18. Iscotin
  19. Isidrina
  20. Ismazide
  21. Isonicotil
  22. BP 5015
  23. Cedin
  24. Cemidon
  25. INH
  26. Inizid
  27. Isobicina
  28. Isocid
  29. Isocidene
  30. Isocotin
  31. Isolyn
  32. Isonerit
  33. Isonex
  34. Isoniazid
  35. Isoniazide
  36. Isonicazide
  37. Isonicid
  38. Isonico
  39. Isonicotan
  40. Isonicotinhydrazid
  41. Isonicotinyl hydrazide
  42. Isonide
  43. Isonidrin
  44. Isonikazid
  45. Isonilex
  46. Isonin
  47. Isonindon
  48. Isonirit
  49. Isoniton
  50. Isonizide
  51. Isonicotinoyl hydrazide
  52. Isonicotinoylhydrazine
  53. Isonicotinsaeurehydrazid (German)
  54. Isotinyl
  55. Isotebe
  56. Isotebezid
  57. Isozide
  58. Isozyd
  59. L 1945
  60. Laniazid
  61. Mybasan
  62. Neumandin
  63. Neoteben
  64. Neo - tizide
  65. Neoxin
  66. Nevin
  67. Niadrin
  68. Nicazide
  69. Nicetal
  70. Nicizina
  71. Niconyl
  72. Nicotibina
  73. Nicozide
  74. Nidaton
  75. Nidrazid
  76. Nikozid
  77. Niplen
  78. Nitadon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate TXAPA9 4,44,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		90 mg/kg MUREAV 56,289,1978
cytogenetic analysis oral
hamster 		10 mg/kg/2 week- intermittent HUGEDQ 42,9,1978
cytogenetic analysis hamster lung 1 gm/L AMONDS 3,253,1980
cytogenetic analysis hamster fibroblast 3 gm/L ESKHA5 (96),55,1978
cytogenetic analysis human lymphocyte 7 mmol/L HUGEDQ 52,309,1979
cytogenetic analysis human leukocyte 5 gm/L EXPEAM 29,1433,1973
cytogenetic analysis human bone marrow 5 mg/L CRSBAW 169,1326,1975
cytogenetic analysis intraperitoneal
mouse 		14,667 µg/kg NULSAK 22,96,1979
cytogenetic analysis mouse Ascites tumor 1 mmol/L PHARAT 32,178,1977
cytogenetic analysis mouse mammary gland 3,200 µmol/L/24 hour- continuous JTSCDR 5,141,1980
cytogenetic analysis intraperitoneal
mouse 		14,700 µg/kg NULSAK 22,96,1979
cytogenetic analysis oral
rat 		900 mg/kg/12 week- intermittent HUGEDQ 42,9,1978
cytogenetic analysis intravenous
rat 		65 mg/kg LANCAO 2,93,1971
DNA adduct oral
mouse 		28 mg/kg HUTODJ 6,153,1987
DNA damage intraperitoneal
mouse 		960 µmol/kg CNREA8 41,1469,1981
DNA inhibition hamster ovary 10 mmol/L MUREAV 50,251,1978
DNA inhibition human HeLa cell 300 mmol/L JOUOD4 8(Suppl),291,1986
DNA inhibition human fibroblast 10 mmol/L MUREAV 89,9,1981
DNA inhibition intraperitoneal
mouse 		90 mg/kg IJEBA6 19,939,1981
DNA repair Escherichia coli 187 µg/well MUREAV 133,161,1984
DNA repair other microorganisms 7 mg/plate BIZNAT 95,463,1976
unscheduled DNA synthesis human liver 100 µmol/L CALEDQ 30,103,1986
host-mediated assay guinea pig
Salmonella typhimurium 		150 mg/kg MUREAV 41,89,1976
host-mediated assay hamster
Salmonella typhimurium 		150 mg/kg MUREAV 41,89,1976
host-mediated assay mouse
Salmonella typhimurium 		150 mg/kg MUREAV 41,89,1976
host-mediated assay mouse
Escherichia coli 		150 mg/kg MUREAV 164,19,1986
host-mediated assay rat
Salmonella typhimurium 		150 mg/kg MUREAV 41,89,1976
mutation in microorganisms other microorganisms 156 mg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms other microorganisms 1,500 mg/L (+enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) CRNGDP 5,391,1984
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) BIZNAT 97,137,1978
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L MUREAV 91,215,1981
other mutation test systems Bacillus subtilis 10 mmol/L MUREAV 5,343,1968
other mutation test systems human lymphocyte 10 mmol/L MUREAV 50,251,1978
other mutation test systems intraperitoneal
mouse 		14,667 µg/kg NULSAK 22,96,1979
sister chromatid exchange hamster ovary 1 mmol/L MUREAV 68,351,1979
sister chromatid exchange hamster lung 10 mmol/L HUGEDQ 54,155,1980
specific locus test intraperitoneal
mouse 		100 mg/kg PJPPAA 31,689,1979
sperm morphology intraperitoneal
mouse 		900 mg/kg REBPAT 13,1,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,848 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Delayed effects 		IJEBA6 18,1104,1980
oral
rabbit 		lowest published toxic dose: 40 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		DPHFAK 23,383,1971
subcutaneous
mouse 		lowest published toxic dose: 160 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		GJMSA7 14,233,1965
subcutaneous
rat 		lowest published toxic dose: 2,790 µg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		DPHFAK 23,383,1971
subcutaneous
rat 		lowest published toxic dose: 27,900 µg/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		DPHFAK 23,383,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 2,200 mg/kg/8 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease 		UICMAI 7,180,1967
intraperitoneal
mouse 		toxic dose : 2,240 mg/kg/32 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JLCMAK 60,1025,1962
oral
mouse 		lowest published toxic dose: 1,892 mg/kg (multigenerations) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors 		JCROD7 105,258,1983
oral
mouse 		lowest published toxic dose: 18,524 mg/kg/84 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JCROD7 105,258,1983
oral
mouse 		toxic dose : 93 gm/kg/70 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		CNREA8 26,1473,1966
oral
mouse 		toxic dose : 15 gm/kg/30 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GANNA2 51,83,1960
oral
mouse 		toxic dose : 27 gm/kg/49 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		JNCIAM 41,331,1968
oral
mouse 		toxic dose : 79,576 mg/kg/98 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TUMOAB 56,315,1970
oral
mouse 		toxic dose : 8,880 mg/kg/19 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GANNA2 50,107,1959
oral
mouse 		toxic dose : 9 gm/kg/17 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		IJCNAW 21,381,1978
oral
mouse 		toxic dose : 2,240 mg/kg/4 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		BJCAAI 18,543,1964
oral
mouse 		toxic dose : 6,720 mg/kg/32 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JLCMAK 60,1025,1962
oral
rat 		lowest published toxic dose: 55 gm/kg/45 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JNCIAM 41,331,1968
subcutaneous
mouse 		lowest published toxic dose: 5,040 mg/kg/18 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GANNA2 51,83,1960
subcutaneous
mouse 		toxic dose : 269 mg/kg/21 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors 		JCROD7 96,163,1980
unreported route
mouse 		lowest published toxic dose: 27,400 mg/kg/39 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		PAPOAC 12,53,1961


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rabbit 		lethal dose (50 percent kill): >12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
intramuscular
guinea pig 		lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
intramuscular
mouse 		lethal dose (50 percent kill): 137 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		ARTUA4 65,376,1952
intramuscular
rat 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Convulsions or effect on seizure threshold THERAP 8,62,1953
intramuscular
rabbit 		lethal dose (50 percent kill): 155 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
intraperitoneal
cat 		lethal dose (50 percent kill): 325 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KLWOAZ 30,959,1952
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 195 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KLWOAZ 30,959,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
mouse 		lowest published toxic dose: 250 mg/kg N/R JOETD7 76,145,2001
intraperitoneal
mouse 		lowest published toxic dose: 250 mg/kg Behavioral: Muscle contraction or spasticity JOETD7 76,145,2001
intraperitoneal
rat 		lethal dose (50 percent kill): 335 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
intraperitoneal
rat 		lowest published toxic dose: 250 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JPETAB 294,473,2000
intraperitoneal
rabbit 		lethal dose (50 percent kill): 147 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
intravenous
guinea pig 		lethal dose (50 percent kill): 220 mg/kg Gastrointestinal: Hypermotility, diarrhea ATXKA8 22,80,1966
intravenous
mouse 		lethal dose (50 percent kill): 149 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 122,110,1958
intravenous
rat 		lethal dose (50 percent kill): 365 mg/kg N/R ARZNAD 26,409,1976
intravenous
rabbit 		lethal dose (50 percent kill): 94 mg/kg Behavioral: Convulsions or effect on seizure threshold ARTUA4 65,376,1952
oral
child 		lowest published toxic dose: 195 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Headache 		JJTOEX 12,225,1999
oral
child 		lowest published toxic dose: 3,600 mg/kg/43 week- intermittent Eye: Other eye effects

Behavioral: Tremor

Behavioral: Ataxia 		CMAJAX 148,49,1993
oral
child 		lowest published toxic dose: 125 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		AEMED3 17,73,1988
oral
dog 		lethal dose (50 percent kill): 50 mg/kg N/R ARTUA4 65,392,1952
oral
guinea pig 		lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
oral
human 		lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath ARDSBL 105,206,1972
oral
human 		lowest published toxic dose: 91.7 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		JTCTDW 39,143,2001
oral
infant 		lowest published toxic dose: 91 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		PEDIAU 95,700,1995
oral
man 		lowest published lethal dose: 523 mg/kg/17 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) 		JAMAAP 176,877,1961
oral
man 		lowest published toxic dose: 430 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold 		NEURAI 20,299,1970
oral
man 		lowest published toxic dose: 39 mg/kg/9 day- intermittent Skin: After systemic exposure: Dermatitis, other SMJOAV 75,81,1982
oral
man 		lowest published toxic dose: 100 mg/kg/3 week- continuous Behavioral: Anorexia (human)

Skin and Appendages: Other: Sweating

Kidney, Ureter, and Bladder: Other changes 		ARDSBL 106,849,1972
oral
man 		lowest published lethal dose: 116 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema 		JATOD3 16,57,1992
oral
mouse 		lethal dose (50 percent kill): 133 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		ARTUA4 65,376,1952
oral
rat 		lethal dose (50 percent kill): 1,250 mg/kg N/R ARZNAD 26,409,1976
oral
rabbit 		lethal dose (50 percent kill): 250 mg/kg N/R ARZNAD 12,22,1962
oral
woman 		lowest published toxic dose: 90,200 µg/kg/7 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Cardiac: EKG changes not diagnostic of above 		PEDIAU 97,782,1996
oral
woman 		lowest published toxic dose: 99,300 µg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		PEDIAU 95,700,1995
oral
woman 		lowest published toxic dose: 12 mg/kg/2 day- intermittent Behavioral: Toxic psychosis

Behavioral: Ataxia 		NEURAI 34,703,1984
oral
woman 		lowest published toxic dose: 11,250 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		ANASAB 47,781,1992
subcutaneous
guinea pig 		lethal dose (50 percent kill): 195 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952
subcutaneous
mouse 		lethal dose (50 percent kill): 125 mg/kg Behavioral: Convulsions or effect on seizure threshold YKKZAJ 81,1225,1961
subcutaneous
mouse 		lowest published toxic dose: 800 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 298,753,2001
subcutaneous
rat 		lethal dose (50 percent kill): 329 mg/kg N/R JPETAB 119,444,1957
subcutaneous
rabbit 		lethal dose (50 percent kill): 135 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		SZTPA5 9,226,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 280 mg/kg/14 day- intermittent Liver: Change in gall bladder structure or function

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		AMBIEH 30,185,1985
intraperitoneal
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FATOAO 49,86,1986
intraperitoneal
rat 		lowest published toxic dose: 700 mg/kg/14 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		FATOAO 55,45,1992
oral
dog 		lowest published toxic dose: 2,300 mg/kg/17 week- intermittent Brain and Coverings: Other degenerative changes TXAPA9 10,183,1967
oral
dog 		lowest published toxic dose: 577 mg/kg/33 day- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ARTUA4 65,392,1952
oral
dog 		lowest published toxic dose: 325 mg/kg/13 week- intermittent Liver: Other changes ARTUA4 65,376,1952
oral
rat 		lowest published toxic dose: 45 gm/kg/52 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 8,325,1966
oral
rat 		lowest published toxic dose: 166 gm/kg/26 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		JACTDZ 14,328,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 4,159,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,227,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,227,1987
TOXICOLOGY REVIEW
CTOXAO 39,143,2001
TOXICOLOGY REVIEW
AJHPA9 32,202,1975
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
MMWOAU 115,1685,1973
TOXICOLOGY REVIEW
MUREAV 39,111,1977
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
APHRER 38,1074,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1139;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 297
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1139;
Number of Industries 2;
Total Number of Facilities 79;
Number of Occupations 4;
Total Number of Employees Exposed 2,924;
Total Number of Female Employees Exposed 1,480


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rabbit
EPA GENETOX PROGRAM 1988, Inconclusive: Body fluid assay; Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Inconclusive: Mouse spot test; Mouse specific locus
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AJHPA9 American Journal of Hospital Pharmacy. (American Soc. of Hospital Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.15- 1958-
AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32, 1985-1987
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
ANASAB Anaesthesia. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1946-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54. For publisher information, see ARDSBL.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
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Used as an antitubercular, antibacterial and anti-actinomycotic agent

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 7640-37-1
ALT CAS #: 37271-10-6
ALT CAS #: 41466-07-3
ALT CAS #: 62229-51-0
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