International Chemical Safety Cards FUMARIC ACID ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid C4H4O4 / COOHCH=CHCOOH Molecular mass: 116.1 ICSC #    1173 CAS #     110-17-8 RTECS # LS9625000 EC #         607-146-00-X March 15, 1995 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION Cough. Sore throat. Local exhaust or breathing protection. Fresh air, rest.  •SKIN Redness. Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Redness. Pain. Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal cramps. Diarrhoea. Nausea. Do not eat, drink, or smoke during work. Rinse mouth. Give plenty of water to drink. Rest. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting, then remove to safe place (extra personal protection: P2 filter respirator for harmful particles). Xi symbol R: 36 S: 2-26 SEE IMPORTANT INFORMATION ON BACK ICSC: 1173 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards FUMARIC ACID ICSC: 1173 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: ODOURLESS, COLOURLESS CRYSTALLINE POWDER. PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: On combustion, forms irritating fumes of maleic anhydride. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes, the skin and the respiratory tract. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Sublimation point: 200°C Relative density (water = 1): 1.63 Solubility in water: 0.63 g/100 ml at 25°C Auto-ignition temperature: (powder) 740°C ENVIRONMENTAL DATA N O T E S Melting point 287°C (closed capillary, rapid heating); partial carbonization and formation of maleic anhydride occur at 230°C (open vessel). Health effects of exposure to the substance have been investigated, but none has been found. ADDITIONAL INFORMATION ICSC: 1173 FUMARIC ACID (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.