The Registry of Toxic Effects of Chemical Substances

Fumaric acid

RTECS #: LS9625000

CAS #: 110-17-8

UPDATE: February 2003 MW: 116.08 MF: C4H4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Allomaleic acid
  2. 1,2 - Ethenedicarboxylic acid, trans -
  3. trans - 1,2 - Ethylenedicarboxylic acid
  4. 1,2 - Ethylenedicarboxylic acid, (E)
  5. Boletic acid
  6. trans - Butenedioic acid
  1. Butenedioic acid, (E) -
  2. Kyselina fumarova (Czech)
  3. Lichenic acid
  4. NSC - 2752
  5. U - 1149
  6. USAF EK - P - 583


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,313,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,313,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition intravenous
rat 		40 mg/kg JJCREP 77,750,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lowest published lethal dose: 587 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Blood: Hemorrhage 		JAPMA8 35,298,1946
oral
rat 		lethal dose (50 percent kill): 9,300 mg/kg N/R TXAPA9 42,417,1977
oral
rabbit 		lowest published lethal dose: 5 gm/kg N/R IECHAD 15,628,1923
unreported route
mouse 		lethal dose (50 percent kill): 5 gm/kg Olfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation 		TOVEFN (2),25,1994
unreported route
rat 		lethal dose (50 percent kill): 6,800 mg/kg Olfaction: Other olfaction effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation 		TOVEFN (2),25,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 28,000 mg/kg/40 week- continuous Gastrointestinal: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent 		VOONC* -,956,1992
oral
rat 		lowest published toxic dose: 36,400 mg/kg/52 week- continuous Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent 		VOONC* -,956,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33940;
Number of Industries 27;
Total Number of Facilities 2,317;
Number of Occupations 44;
Total Number of Employees Exposed 30,637
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33940;
Number of Industries 40;
Total Number of Facilities 5,692;
Number of Occupations 58;
Total Number of Employees Exposed 136,448;
Total Number of Female Employees Exposed 48,919


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of resins, polyesters, plasticizers, and alkyl surface coatings
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-

Used in production of resins, polyesters, plasticizers, and alkyl surface coatings

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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