International Chemical Safety Cards HEXAFLUOROACETONE ICSC: 1057 1,1,1,3,3,3-Hexafluoro-2-propanone Perfluoroacetone C3F6O / CF3COCF3 Molecular mass: 166.0 ICSC #    1057 CAS #     684-16-2 RTECS # UC2450000 UN #        2420 October 04, 2000 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: all extinguishing agents allowed. EXPLOSION In case of fire: keep cylinder cool by spraying with water. EXPOSURE STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!  •INHALATION Cough. Sore throat. Burning sensation. Laboured breathing. Shortness of breath. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention.  •SKIN MAY BE ABSORBED! Redness. Pain. ON CONTACT WITH LIQUID: FROSTBITE. Cold-insulating gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes.  •EYES Redness. Pain. Safety spectacles, face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert in case of a large spill! Ventilation. Remove gas with fine water spray. (Extra personal protection: complete protective clothing including self-contained breathing apparatus). Fireproof if in building. Cool. R: S: UN Hazard Class: 2.3 UN Subsidiary Risks: 8 SEE IMPORTANT INFORMATION ON BACK ICSC: 1057 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards HEXAFLUOROACETONE ICSC: 1057 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS GAS , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: The gas is heavier than air. CHEMICAL DANGERS: The substance decomposes on heating at 550°C producing toxic and corrosive fumes . Reacts vigorously with water and moisture to form a highly acidic hydrates. Attacks glass and most metal s. OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.1 ppm; 0.68 mg/m3 (skin) (ACGIH 2000). MAK not established. OSHA PEL: none NIOSH REL: TWA 0.1 ppm (0.7 mg/m3) skin NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and through the skin. INHALATION RISK: A harmful concentration of this gas in the air will be reached very quickly on loss of containment. EFFECTS OF SHORT-TERM EXPOSURE: The substance is severely irritating to the eyes, the skin and the respiratory tract. Inhalation of this gas may cause lung oedema (see Notes). Rapid evaporation of the liquid may cause frostbite. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes malformations in human babies. Animal tests show that this substance possibly causes toxic effects upon human reproduction. PHYSICAL PROPERTIES Boiling point: -28°C Melting point: -129°C Relative density: 1.33 g/ml at 25°C (liquid) Solubility in water: reaction , releasing heat Relative vapour density (air = 1): 5.7 Octanol/water partition coefficient as log Pow: 1.46 ENVIRONMENTAL DATA N O T E S The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. Transport Emergency Card: TEC (R)-20G42 ADDITIONAL INFORMATION ICSC: 1057 HEXAFLUOROACETONE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.