RTECS:UC2450000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

2 - Propanone, 1,1,1,3,3,3 - hexafluoro -

RTECS #: UC2450000

CAS #: 684-16-2

UPDATE: November 2004 MW: 166.03 MF: C₃F₆O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

6FK

Acetone, hexafluoro -

Hexafluoroacetone

Hexafluoroacetone (ACGIH)

NCI - C56440

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 12 ppm/6 hour (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 67,249,1991
skin
rat lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 2,73,1982
skin
rat lowest published toxic dose: 55 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 41,195,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published lethal concentration: 30,600 mg/m³/45 minute Vascular: BP lowering not characterized in autonomic section VCVGK* -,437,1994
inhalation
rat lethal concentration (50 percent kill): 275 ppm/3 hour N/R TXAPA9 6,341,1964
inhalation
rat lethal concentration (50 percent kill): 5,520 mg/m³/30 minute Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes VCVGK* -,437,1994
inhalation
rat lethal concentration (50 percent kill): 1,690 mg/m³/3 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes VCVGK* -,437,1994
oral
rat lethal dose (50 percent kill): 191 mg/kg N/R TXAPA9 6,341,1964
skin
rat lowest published toxic dose: 13 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,437,1994
skin
rat lowest published toxic dose: 39 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVGK* -,437,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rat lowest published toxic dose: 117 mg/kg/3 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,437,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.7 mg/m³) DTLWS* 3,20,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.7 mg/m³), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.68 mg/m³), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.7 mg/m³), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m³, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm (skin)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXAFLUOROACETONE-air 10 hour time-weighted average 0.1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83899;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 1;
Total Number of Employees Exposed 141

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a chemical intermediate

NIOSH PROFILE (HEXAFLUOROACETONE), SRC, 10/77

RTECS Compound Description:
Reproductive Effector

Click Here for Additional Information about RTECS

SYNONYMS:
6FK Acetone, hexafluoro - Hexafluoroacetone	Hexafluoroacetone (ACGIH) NCI - C56440

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 12 ppm/6 hour (30 day male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 67,249,1991
skin rat	lowest published toxic dose: 100 mg/kg (6-15 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAATDF 2,73,1982
skin rat	lowest published toxic dose: 55 mg/kg (6-16 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 41,195,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation dog	lowest published lethal concentration: 30,600 mg/m³/45 minute	Vascular: BP lowering not characterized in autonomic section	VCVGK* -,437,1994
inhalation rat	lethal concentration (50 percent kill): 275 ppm/3 hour	N/R	TXAPA9 6,341,1964
inhalation rat	lethal concentration (50 percent kill): 5,520 mg/m³/30 minute	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes	VCVGK* -,437,1994
inhalation rat	lethal concentration (50 percent kill): 1,690 mg/m³/3 hour	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes	VCVGK* -,437,1994
oral rat	lethal dose (50 percent kill): 191 mg/kg	N/R	TXAPA9 6,341,1964
skin rat	lowest published toxic dose: 13 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,437,1994
skin rat	lowest published toxic dose: 39 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VCVGK* -,437,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rat	lowest published toxic dose: 117 mg/kg/3 day- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,437,1994

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 0.1 ppm (skin)	DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 0.1 ppm (0.7 mg/m³)	DTLWS* 3,20,1973
Occupational Exposure Limit - AUSTRALIA	time-weighted average 0.1 ppm (0.7 mg/m³), Skin, JAN1993
Occupational Exposure Limit - BELGIUM	time-weighted average 0.1 ppm (0.68 mg/m³), Skin, JAN1993
Occupational Exposure Limit - DENMARK	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE	VME 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY	time-weighted average 0.1 ppm (0.7 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND	MAK- week 0.1 ppm (0.7 mg/m³), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 0.05 mg/m³, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXAFLUOROACETONE-air	10 hour time-weighted average 0.1 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83899; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 1; Total Number of Employees Exposed 141

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS*	"Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.