International Chemical Safety Cards BRUCINE, ANHYDROUS ICSC: 1017 10,11-Dimethoxystrychnine 2,3-Dimethoxystrychnidin-10-one 2,3-Dimethylstrychnine Dimethoxystrychnine C23H26N2O4 Molecular mass: 394.47 ICSC #    1017 CAS #     357-57-3 RTECS # EH8925000 UN #        1570 EC #         614-006-00-1 March 06, 2002 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!  •INHALATION See Ingestion. Ventilation (not if powder), local exhaust, or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Headache. Nausea. Vomiting. Twiching. Excitement. Restlessness. Convulsions. Laboured breathing. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. Keep victim completely undisturbed. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles.) Do NOT let this chemical enter the environment. Separated from strong oxidants, food and feedstuffs . Dry. Well closed. Do not transport with food and feedstuffs. T+ symbol R: 26/28-52/53 S: 1/2-13-45-61 UN Hazard Class: 6.1 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 1017 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards BRUCINE, ANHYDROUS ICSC: 1017 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS OR WHITE CRYSTALLINE POWDER PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes including nitrogen oxides . The solution in water is a weak base. Reacts with strong oxidants , causing fire and explosion hazard. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: May cause mechanical irritation. The substance may cause effects on the nervous system and eyes , resulting in convulsions and respiratory paralysis. Exposure may result in death. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 470°C Melting point: 178°C Solubility in water: poor Octanol/water partition coefficient as log Pow: 0.98 ENVIRONMENTAL DATA The substance is harmful to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds. N O T E S Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The recommendations on this Card also apply to Brucine hydrate (CAS 5892-11-5). Transport Emergency Card: TEC (R)-61GT2-I ADDITIONAL INFORMATION ICSC: 1017 BRUCINE, ANHYDROUS (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.