The Registry of Toxic Effects of Chemical Substances

Brucine

RTECS #: EH8925000

CAS #: 357-57-3

UPDATE: February 2005 MW: 394.51 MF: C23H26N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Brucina (Italian)
  2. ( - ) - Brucine
  3. Brucine alkaloid
  4. 2,3 - Dimethoxystrychnidin - 10 - one
  5. Dimethoxy strychnine
  1. 2,3 - Dimethoxy - strychnine
  2. 10,11 - Dimethystrychnine
  3. RCRA waste number P018
  4. Strychnidin - 10 - one, 2,3 - dimethoxy - (9CI)
  5. Strychnine, 2,3 - dimethoxy -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 62 mg/kg Behavioral: Convulsions or effect on seizure threshold JOETD7 35,295,1992
intraperitoneal
mouse 		lowest published toxic dose: 10.3 mg/kg Behavioral: Analgesia JOETD7 88,205,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 91 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Rigidity (includes catalepsy)

Behavioral: Muscle contraction or spasticity 		JPETAB 131,185,1961
intraperitoneal
rat 		lowest published toxic dose: 15 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JOETD7 88,205,2003
intraperitoneal
rat 		lowest published toxic dose: 7 mg/kg Behavioral: Analgesia JOETD7 88,205,2003
intravenous
dog 		lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1289,1935
intravenous
guinea pig 		lowest published lethal dose: 120 mg/kg N/R NTIS** PB214-270
intravenous
mouse 		lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold JOETD7 35,295,1992
intravenous
rabbit 		lowest published lethal dose: 30 mg/kg N/R NTIS** PB214-270
oral
mouse 		lethal dose (50 percent kill): 150 mg/kg Behavioral: Convulsions or effect on seizure threshold JOETD7 35,295,1992
subcutaneous
mouse 		lethal dose (50 percent kill): 60 mg/kg Behavioral: Convulsions or effect on seizure threshold APSXAS 7,329,1970
subcutaneous
pigeon 		lowest published lethal dose: 58 mg/kg N/R HBAMAK 4,1289,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/20 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JOETD7 88,205,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84459;
Number of Industries 2;
Total Number of Facilities 109;
Number of Occupations 3;
Total Number of Employees Exposed 150
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84459;
Number of Industries 2;
Total Number of Facilities 18;
Number of Occupations 2;
Total Number of Employees Exposed 334;
Total Number of Female Employees Exposed 119


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as denaturant for ETHANOL, also resolving agent for isomer separation
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as denaturant for ETHANOL, also resolving agent for isomer separation

RTECS Compound Description:
   Drug
   Natural Product

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