The Registry of Toxic Effects of Chemical Substances
Brucine |
UPDATE: February 2005 | MW: 394.51 | MF: C23H26N2O4 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 62 mg/kg | Behavioral: Convulsions or effect on seizure threshold | JOETD7 35,295,1992 |
intraperitoneal mouse | lowest published toxic dose: 10.3 mg/kg | Behavioral: Analgesia | JOETD7 88,205,2003 |
intraperitoneal rat | lethal dose (50 percent kill): 91 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Rigidity (includes catalepsy) Behavioral: Muscle contraction or spasticity | JPETAB 131,185,1961 |
intraperitoneal rat | lowest published toxic dose: 15 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JOETD7 88,205,2003 |
intraperitoneal rat | lowest published toxic dose: 7 mg/kg | Behavioral: Analgesia | JOETD7 88,205,2003 |
intravenous dog | lowest published lethal dose: 8 mg/kg | N/R | HBAMAK 4,1289,1935 |
intravenous guinea pig | lowest published lethal dose: 120 mg/kg | N/R | NTIS** PB214-270 |
intravenous mouse | lethal dose (50 percent kill): 12 mg/kg | Behavioral: Convulsions or effect on seizure threshold | JOETD7 35,295,1992 |
intravenous rabbit | lowest published lethal dose: 30 mg/kg | N/R | NTIS** PB214-270 |
oral mouse | lethal dose (50 percent kill): 150 mg/kg | Behavioral: Convulsions or effect on seizure threshold | JOETD7 35,295,1992 |
subcutaneous mouse | lethal dose (50 percent kill): 60 mg/kg | Behavioral: Convulsions or effect on seizure threshold | APSXAS 7,329,1970 |
subcutaneous pigeon | lowest published lethal dose: 58 mg/kg | N/R | HBAMAK 4,1289,1935 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal rat | lowest published toxic dose: 300 mg/kg/20 day- intermittent | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JOETD7 88,205,2003 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 84459; Number of Industries 2; Total Number of Facilities 109; Number of Occupations 3; Total Number of Employees Exposed 150 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 84459; Number of Industries 2; Total Number of Facilities 18; Number of Occupations 2; Total Number of Employees Exposed 334; Total Number of Female Employees Exposed 119 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as denaturant for ETHANOL, also resolving agent for isomer separation | |
On EPA IRIS database |
REFERENCES: | |
CODEN |
REFERENCE |
APSXAS | Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- |
HBAMAK | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) |
JOETD7 | Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- |
JPETAB | Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |