International Chemical Safety Cards ISOPRENE ICSC: 0904 2-Methyl-1,3-butadiene beta-Methylbivinyl 2-Methylbutadiene C5H8 / CH2=C(CH3)CH=CH2 Molecular mass: 68.1 ICSC #    0904 CAS #     78-79-5 RTECS # NT4037000 UN #        1218 (inhibited) EC #         601-014-00-5 April 11, 1997 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Extremely flammable. NO open flames, NO sparks, and NO smoking. Powder, AFFF, foam, carbon dioxide. EXPLOSION Vapour/air mixtures are explosive. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. In case of fire: keep drums, etc., cool by spraying with water. EXPOSURE PREVENT GENERATION OF MISTS!  •INHALATION Burning sensation. Cough. Dizziness. Laboured breathing. Nausea. Shortness of breath. Sore throat. Ventilation. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN Redness. Pain. Protective gloves. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Redness. Pain. Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal pain. Burning sensation. Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus. Fireproof. Separated from combustible and reducing substances, strong oxidants, strong bases, strong acids, alcohols , acid chlorides . Cool. Keep in the dark. Well closed. Store only if stabilized. Note: D F+ symbol T symbol R: 45-12-68-52/53 S: 53-45-61 UN Hazard Class: 3 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 0904 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ISOPRENE ICSC: 0904 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: VERY VOLATILE COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. CHEMICAL DANGERS: The substance can readily form explosive peroxides. The substance polymerizes due to heating and under the influence of many materials, with fire or explosion hazard. Reacts with strong oxidants , strong reducing agents , strong acids , strong bases , acid chlorides , alcohols , causing fire and explosion hazard. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the central nervous system , resulting in respiratory depression . Exposure could cause lowering of consciousness. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Lungs may be affected by repeated or prolonged exposure. This substance is possibly carcinogenic to humans. PHYSICAL PROPERTIES Boiling point: 34°C Melting point: -146°C Relative density (water = 1): 0.7 Solubility in water: none Vapour pressure, kPa at 20°C: 53.2 Relative vapour density (air = 1): 2.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.8 Flash point: -54°C c.c. Auto-ignition temperature: 220°C Explosive limits, vol% in air: 1.5-8.9 Octanol/water partition coefficient as log Pow: 2.30 ENVIRONMENTAL DATA The substance is harmfull to aquatic organisms. N O T E S Usually contains inhibitors to prevent polymerization. Data are insufficiently available on the effect of this substance on human health, therefore utmost care must be taken. An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert. Check for peroxides prior to distillation; eliminate if found. Vapours are uninhibited and may polymerize, blocking valves and vents. Card has been partly updated in October 2004. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-30S1218 NFPA Code: H2; F4; R2 ADDITIONAL INFORMATION ICSC: 0904 ISOPRENE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.