The Registry of Toxic Effects of Chemical Substances

Isoprene

RTECS #: NT4037000

CAS #: 78-79-5

UPDATE: May 2005 MW: 68.13 MF: C5H8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Butadiene, 2 - methyl -
  2. Isopentadiene
  3. beta - Methylbivinyl
  1. 2 - Methylbutadiene
  2. 2 - Methyl - 1,3 - butadiene
  3. NSC 9237


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage inhalation
mouse 		700 ppm/26 week- intermittent CBINA8 135-136,373,2001
micronucleus test inhalation
mouse 		438 ppm/6 hour/12 day- continuous MUTAEX 3,141,1988
sister chromatid exchange inhalation
mouse 		438 ppm/6 hour/12 day- continuous MUTAEX 3,141,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 280 ppm (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #DE89008095/XAD
inhalation
mouse 		lowest published toxic concentration: 7,000 ppm (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #DE89008095/XAD
inhalation
rat 		lowest published toxic concentration: 7,000 ppm (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #DE89008095/XAD


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 7,000 ppm/6 hour/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		CNREA8 54,5333,1994
inhalation
mouse 		lowest published toxic concentration: 700 ppm/6 hour/26 week - intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		CBINA8 135-136,373,2001
inhalation
rat 		lowest published toxic concentration: 220 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTPTR* NTP-TR-486,1999
inhalation
rat 		lowest published toxic concentration: 22,050 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Reproductive: Tumorigenic effects: Testicular tumors 		NTIS** PB2000-101651
inhalation
rat 		lowest published toxic concentration: 220,500 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB2000-101651
inhalation
rat 		lowest published toxic concentration: 5,775 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB2000-101651


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 800 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGH* -,65,1990
inhalation
human 		lowest published toxic concentration: 160 mg/m3/1 minute Eye: Conjunctiva irritation VCVGH* -,66,1990
inhalation
mouse 		lethal concentration (50 percent kill): 139 gm/m3/2 hour Lung, Thorax, or Respiration: Other changes GTPZAB 9(1),36,1965
inhalation
mouse 		lethal concentration (50 percent kill): 130,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
mouse 		lethal concentration (16 percent kill): 117,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
mouse 		lethal concentration (84 percent kill): 212,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
rat 		lethal concentration (50 percent kill): 180 gm/m3/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression 		RPTOAN 31,162,1968
inhalation
rat 		lethal concentration (50 percent kill): 129,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rat 		lethal concentration (16 percent kill): 92,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rat 		lethal concentration (84 percent kill): 381,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rabbit 		lowest published toxic concentration: 750 mg/m3/40 minute Lung, Thorax, or Respiration: Dyspnea VCVGH* -,66,1990
inhalation
rabbit 		lowest published toxic concentration: 300 mg/m3 Behavioral: Alteration of classical conditioning VCVGH* -,66,1990
oral
rat 		lowest published lethal dose: 4.5 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGH* -,66,1990
skin
rabbit 		lowest published toxic dose: 0.25 mL/kg Skin: After systemic exposure: Dermatitis, other VCVGH* -,67,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 3,400 mg/m3/17 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in leukocyte (WBC) count 		GTPZAB 9(1),36,1965
inhalation
mouse 		lowest published toxic concentration: 3,400 mg/m3/17 week- intermittent Behavioral: Change in psychophysiological tests GTPZAB 9(1),36,1965
inhalation
mouse 		lowest published toxic concentration: 700 ppm/6 hour/13 week- intermittent Gastrointestinal: Other changes CNREA8 54,5333,1994
inhalation
mouse 		lowest published toxic concentration: 7,000 ppm/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #DE89008095/XAD
inhalation
mouse 		lowest published toxic concentration: 1,400 ppm/14 day- intermittent Liver: Changes in liver weight NTIS** #DE89008095/XAD
inhalation
rat 		lowest published toxic concentration: 3,400 mg/m3/22 week- intermittent Brain and Coverings: Changes in brain weight

Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		GTPZAB 9(1),36,1965
inhalation
rat 		lowest published toxic concentration: 7,000 ppm/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #DE89008095/XAD
intraperitoneal
mouse 		lowest published toxic dose: 14,973.6 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis CRTOEC 8,963,1995
oral
rat 		lowest published toxic dose: 157 mg/kg/9 week- continuous Behavioral: Alteration of classical conditioning GISAAA 24(6),8,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,215,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1015,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,215,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1015,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1015,1999
TOXICOLOGY REVIEW
CBINA8 135-136,27,2001
TOXICOLOGY REVIEW
CBINA8 135-136,65,2001
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 40 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40940;
Number of Industries 36;
Total Number of Facilities 2,278;
Number of Occupations 43;
Total Number of Employees Exposed 58,102
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40940;
Number of Industries 6;
Total Number of Facilities 123;
Number of Occupations 15;
Total Number of Employees Exposed 3,703;
Total Number of Female Employees Exposed 578


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of cis-1,4-POLYISOPRENE RUBBER, STYRENE/ISOPRENE/STYRENE block polymers
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8707
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-31, October 2000


REFERENCES:

CODEN
REFERENCE
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of cis-1,4-POLYISOPRENE RUBBER, STYRENE/ISOPRENE/STYRENE block polymers

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 78006-92-5
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