International Chemical Safety Cards ISOPHORONE DIISOCYANATE ICSC: 0499 3-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester IPDI C12H18N2O2 / (CH3)2C6H7(CH3)(N=C=O)CH2N=C=O Molecular mass: 222,3 ICSC #    0499 CAS #     4098-71-9 RTECS # NQ9370000 UN #        2290 EC #         615-008-00-5 March 25, 1999 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Cough. Laboured breathing. Sore throat. Wheezing. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.  •SKIN Redness. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Redness. Pain. Safety goggles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Burning sensation. Sore throat. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Rest. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Treat remaining liquid with dilute ammonia solution. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus. Separated from bases, acids, alcohols , amines , amides, phenols, mercaptans, food and feedstuffs . See Chemical Dangers. Cool. Dry. Airtight. Do not transport with food and feedstuffs. Note: 2 T symbol N symbol R: 23-36/37/38-42/43-51/53 S: 1/2-26-28-38-45-61 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0499 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ISOPHORONE DIISOCYANATE ICSC: 0499 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO YELLOW LIQUID , WITH PUNGENT ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance may polymerize due to warming and under the influence of strong bases and metal compounds. May explode on heating. The substance decomposes on burning producing toxic fumesincludingnitrogen oxides,hydrogen cyanide,carbon monoxide, carbon dioxide. Reacts slowly with water at room temperature, vigorously at high temperature; violently with alcohols, acids, bases, amines, amides, phenols, mercaptanes. Attacks plastic and rubber. OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.005 ppm; (ACGIH 2004). MAK: 0.01 ppm, 0.092 mg/m³; Sah; Peak limitation category: I(1); (DFG 2004). OSHA PEL: none NIOSH REL: TWA 0.005 ppm (0.045 mg/m3) ST 0.02 ppm (0.180 mg/m3) skin NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly especially on spraying and heating. EFFECTS OF SHORT-TERM EXPOSURE: The substance and the aerosol is irritating to the eyes the skin and the respiratory tract . Inhalation of aerosol may cause lung oedema (see Notes). Inhalation of aerosols may cause asthmatic reactions (see Notes). The substance may cause effects on the skin , resulting in sensitization. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma. PHYSICAL PROPERTIES Boiling point at 13.3kPa: 217°C Melting point: -60°C Relative density (water = 1): 1.1 Solubility in water: reaction Vapour pressure, Pa at 20°C: 0.04 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0 Flash point: 155°C c.c. Auto-ignition temperature: 430°C Explosive limits, vol% in air: 0.7-4.5 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S Temperature of decomposition unknown in literature. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. The symptoms of acute intoxications may not become manifest until several hours. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. Card has been partly updated in October 2004. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-61S2290 NFPA Code: H2; F1; R1; W ADDITIONAL INFORMATION ICSC: 0499 ISOPHORONE DIISOCYANATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.