The Registry of Toxic Effects of Chemical Substances

Isocyanic acid, methylene (3,5,5 - trimethyl - 3,1 - cyclohexylene) ester

RTECS #: NQ9370000

CAS #: 4098-71-9

UPDATE: February 2005 MW: 222.32 MF: C12H18N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Isocyanatomethyl - 3,5,5 - trimethylcyclohexylisocyanate
  2. Cyclohexane, 5 - isocyanato - 1 - (isocyanatomethyl) - 1,3,3 - trimethyl - (9CI)
  3. IPDI
  1. Isophorone diamine diisocyanate
  2. Isophorone diisocyanate
  3. Isophorone diisocyanate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 415 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) WDZAEK 5,178,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 118 mg/m3/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0543418
inhalation
rat 		lethal concentration (50 percent kill): 123 mg/m3/4 hour N/R 85INA8 5,334(86),1986
oral
cat 		lethal dose (50 percent kill): 1 mL/kg N/R NTIS** OTS0528418
oral
mouse 		lowest published lethal dose: 2,500 µL/kg N/R NTIS** OTS0528418
oral
rat 		lethal dose (50 percent kill): 4,825 mg/kg N/R NTIS** OTS0530238
skin
rat 		lowest published lethal dose: 1 mL/kg N/R NTIS** OTS0528418


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,370 µg/m3/4 hour/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0528418
skin
mouse 		lowest published toxic dose: 0.3 pph/2 day- intermittent Blood: Other changes

Skin: After topical application: Cutaneous sensitization (experimental) 		TOXID9 72,101,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.09 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.045 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.045 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.09 mg/m3), VLE 0.02 ppm (0.18 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.09 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.045 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.09 mg/m3), KZG- week 0.02 ppm (0.18 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.005 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.005 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IPDI-air 10 hour time-weighted average 0.005 ppm (Sk);
short term exposure limit 0.02 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83571;
Number of Industries 4;
Total Number of Facilities 111;
Number of Occupations 19;
Total Number of Employees Exposed 3,441
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83571;
Number of Industries 15;
Total Number of Facilities 1,186;
Number of Occupations 16;
Total Number of Employees Exposed 7,245;
Total Number of Female Employees Exposed 682


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

RTECS Compound Description:
   Reproductive Effector

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