International Chemical Safety Cards

COUMAPHOS

ICSC: 0422

O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
C₁₄H₁₆ClO₅PS
Molecular mass: 362.78

ICSC #    0422
CAS #     56-72-4
RTECS # GN6300000
UN #        3027
EC #         015-038-00-3
October 07, 1997 Peer reviewed

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: powder, water spray, foam, carbon dioxide.
EXPLOSION

EXPOSURE		PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!	IN ALL CASES CONSULT A DOCTOR!
•INHALATION	Convulsions. Dizziness. Sweating. Laboured breathing. Nausea. Unconsciousness. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed (see Notes).	Local exhaust or breathing protection.	Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
•SKIN	MAY BE ABSORBED! (Further see Inhalation).	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES		Face shield, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	Abdominal cramps. Diarrhoea. Vomiting. (Further see Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Do NOT wash away into sewer. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: complete protective clothing including self-contained breathing apparatus).

Separated from food and feedstuffs . Well closed. Keep in a well-ventilated room.

Do not transport with food and feedstuffs.
Severe
marine pollutant.
T+ symbol
N symbol
R: 21-28-50/53
S: 1/2-28-36/37-45-60-61
UN Hazard Class: 6.1

SEE IMPORTANT INFORMATION ON BACK

ICSC: 0422

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

COUMAPHOS

ICSC: 0422

I

M

P

O

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T

A

N

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D

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T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes including sulfur oxides , phosphorus oxides and hydrogen chloride . Reacts slowly with bases to be hydrolyzed.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL
PROPERTIES

Melting point: 91°C
Density: 1.47
g/cm3
Solubility in water:
none

Vapour pressure, Pa at 20°C: 0.000013
Octanol/water partition coefficient as log Pow: 4.13

ENVIRONMENTAL
DATA

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to fish, crustacea, birds and mammals. In the food chain important to humans, bioaccumulation takes place, specifically in fish. Avoid release to the environment in circumstances different to normal use.

N O T E S

Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Asuntol, Co-ral, Meldane, Muscatox, Perizin, Resitox, Negashunt are trade names.

Transport Emergency Card: TEC (R)-61G41a

ADDITIONAL INFORMATION

ICSC: 0422	COUMAPHOS
(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.