The Registry of Toxic Effects of Chemical Substances

Coumarin, 3 - chloro - 7 - hydroxy - 4 - methyl - , O - ester with O,O - diethyl phosphorothioate

RTECS #: GN6300000

CAS #: 56-72-4

UPDATE: August 2003 MW: 362.78 MF: C14H16ClO5PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Agridip
  2. Asunthol
  3. Asuntol
  4. Azunthol
  5. BAY 21/199
  6. Bayer 21/199
  7. Baymix
  8. Baymix 50
  9. 3 - Chloro - 7 - hydroxy - 4 - methyl - coumarin O,O - diethyl phosphorothioate
  10. 3 - Chloro - 7 - hydroxy - 4 - methyl - coumarin O - ester with O,O - diethyl phosphorothioate
  11. 3 - Chloro - 4 - methyl - 7 - coumarinyl diethyl phosphorothioate
  12. O - 3 - Chloro - 4 - methyl - 7 - coumarinyl O,O - diethyl phosphorothioate
  13. 3 - Chloro - 4 - methyl - 7 - hydroxycoumarin diethyl thiophosphoric acid ester
  14. 3 - Chloro - 4 - methylumbelliferone O - ester with O,O - diethyl phosphorothioate
  15. CO - Ral
  16. Coumafos
  17. Coumaphos
  18. Cumafos (Dutch)
  19. O,O - Diaethyl - O - (3 - chlor - 4 - methyl - cumarin - 7 - yl) - monothiophosphat (German)
  20. ENT 17,957
  21. Meldane
  1. Meldone
  2. Muscatox
  3. NCI - C08662
  4. Negashunt
  5. Phosphorothioic acid, O,O - diethyl ester, O - ester with 3 - chloro - 7 - hydroxy - 4 - methylcoumarin
  6. Resistox
  7. Resitox
  8. Suntol
  9. Thiophosphate de O,O - diethyle et de O - (3 - chloro - 4 - methyl - 7 - coumarinyle) (French)
  10. O,O - Diethyl - O - (3 - chloor - 4 - methyl - cumarin - 7 - yl) monothiofosfaat (Dutch)
  11. O,O - Diethyl O - (3 - chloro - 4 - methyl - 7 - coumarinyl) phosphorothioate
  12. O,O - Diethyl O - (3 - chloro - 4 - methylcoumarinyl - 7) thiophosphate
  13. O,O - Diethyl O - (3 - chloro - 4 - methyl - 2 - oxo - 2H - benzopyran - 7 - yl) phosphorothioate
  14. O,O - Diethyl 3 - chloro - 4 - methyl - 7 - umbelliferone thiophosphate
  15. O,O - Diethyl O - (3 - chloro - 4 - methylumbelliferyl) phosphorothioate
  16. Diethyl 3 - chloro - 4 - methylumbelliferyl thionophosphate
  17. Diethyl thiophosphoric acid ester of 3 - chloro - 4 - methyl - 7 - hydroxycoumarin
  18. O,O - Dietil - O - (3 - cloro - 4 - metil - cumarin - 7 - il - monotiofosfato) (Italian)
  19. Diolice
  20. Umbethion


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform rat embryo 1,400 ng/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 394 mg/kg (multigeneration) Reproductive: Effects on newborn: Biochemical and metabolic REPTED 12,619,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 303 mg/m3 N/R VHTODE 24,87,1982
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 140 mg/kg N/R PCOC** -,282,1966
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 7,500 µg/kg N/R PSEBAA 129,699,1968
oral
wild bird 		lethal dose (50 percent kill): 1,780 µg/kg N/R ASTTA8 (680),157,1979
oral
chicken 		lethal dose : >400 mg/kg Brain and Coverings: Other degenerative changes

Gastrointestinal: Hypermotility, diarrhea

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VHTODE 41,290,1999
oral
duck 		lethal dose (50 percent kill): 29,800 µg/kg N/R DOEAAH 35,25,1979
oral
domestic animal 		lethal dose (50 percent kill): 22,600 µg/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		AJVRAH 41,1857,1980
oral
guinea pig 		lethal dose (50 percent kill): 58 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
oral
man 		lowest published toxic dose: 165 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of exocrine pancreas 		PGMJAO 57,660,1981
oral
mouse 		lethal dose (50 percent kill): 28 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
oral
pigeon 		lethal dose (50 percent kill): 5,620 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 13,300 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 13 mg/kg N/R DOEAAH 35,25,1979
oral
rabbit 		lethal dose (50 percent kill): 80 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968
skin
wild bird 		lethal dose (50 percent kill): 7,500 µg/kg N/R TXAPA9 26,154,1973
skin
rat 		lethal dose (50 percent kill): 860 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R VHTODE 24,87,1982
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 55 mg/kg N/R 30ZDA9 -,341,1971
unreported route
rabbit 		lethal dose (50 percent kill): 2,600 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AJOPAA 53,512,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 168 mg/kg/28 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 33(10-12),334,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
PMDCAY 10,85,1974
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,105,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
Used for control of a wide variety of livestock insects
On EPA IRIS database
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-96,1979


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used for control of a wide variety of livestock insects

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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