International Chemical Safety Cards ANTIPYRINE ICSC: 0376 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one 2,3-Dimethyl-1-phenyl-3-pyrazolin-3-one Phenazone C11H12N2O Molecular mass: 188.2 ICSC #    0376 CAS #     60-80-0 RTECS # CD2450000 March 26, 1996 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE!  •INHALATION Blue lips or finger nails. Blue skin. Shortness of breath. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Protective gloves.  •EYES Pain. Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Blue lips or fingernails. Blue skin. Do not eat, drink, or smoke during work. Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P2 filter respirator for harmful particles. Separated from strong oxidants. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 0376 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ANTIPYRINE ICSC: 0376 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS OR WHITE POWDER. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic and corrosive fumes of nitrogen oxides . Reacts with oxidants. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of the dust and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes and the respiratory tract . The substance may cause effects on the blood , resulting in formation of methaemoglobin. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 319°C Melting point: 113°C Relative density (water = 1): 1.19 Solubility in water: very good ENVIRONMENTAL DATA N O T E S ADDITIONAL INFORMATION ICSC: 0376 ANTIPYRINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.