The Registry of Toxic Effects of Chemical Substances

Antipyrine

RTECS #: CD2450000

CAS #: 60-80-0

UPDATE: May 2005 MW: 188.25 MF: C11H12N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Analgesine
  2. Anodynin
  3. Anodynine
  4. Antipirin
  5. Antipyrin
  6. Apirelina
  7. Azophen
  8. Azophene
  9. 1,2 - Dihydro - 1,5 - dimethyl - 2 - phenyl - 3H - pyrazol - 3 - one
  10. Dimethyloxychinizin
  11. Dimethyloxyquinazine
  12. 2,3 - Dimethyl - 1 - phenyl - 3 - pyrazolin - 5 - one
  13. 2,3 - Dimethyl - 1 - phenyl - 5 - pyrazolone
  14. Fenazon (Czech)
  15. Fenazone
  16. Methozin
  1. Oxydimethylquinazine
  2. Parodyne
  3. Phenazon
  4. Phenazone
  5. Phenazonum
  6. Phenazone (pharmaceutical)
  7. Phenylon
  8. Phenylone
  9. Pyrazophyl
  10. 3H - Pyrazol - 3 - one, 1,2 - dihydro - 1,5 - dimethyl - 2 - phenyl - (9CI)
  11. Sedatin
  12. Sedatine
  13. Phenozone
  14. 1 - Phenyl - 2,3 - dimethylpyrazole - 5 - one
  15. 1 - Phenyl - 2,3 - dimethyl - 5 - pyrazolone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human HeLa cell 80 mmol/L CRNGDP 13,2389,1992
sister chromatid exchange intraperitoneal
mouse 		100 mg/kg MUREAV 420,15,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 361 gm/kg/92 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors 		IJCNAW 27,521,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R AIPTAK 135,376,1962
intravenous
cat 		lowest published lethal dose: 525 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		JPETAB 39,177,1930
intravenous
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R ARZNAD 10,686,1960
intravenous
rabbit 		lowest published lethal dose: 600 mg/kg N/R HBTXAC 5,14,1959
oral
cat 		lowest published lethal dose: 1,250 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		JPETAB 39,177,1930
oral
dog 		lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1304,1935
oral
guinea pig 		lowest published lethal dose: 1,400 mg/kg N/R HBTXAC 5,14,1959
oral
mouse 		lethal dose (50 percent kill): 1,310 mg/kg N/R JAPMA8 45,137,1956
oral
rat 		lethal dose (50 percent kill): 1,705 mg/kg N/R ARZNAD 9,401,1959
rectal
cat 		lowest published lethal dose: 800 mg/kg N/R JAPMA8 33,10,1944
subcutaneous
cat 		lowest published lethal dose: 700 mg/kg N/R HBAMAK 4,1304,1935
subcutaneous
frog 		lowest published lethal dose: 2 gm/kg N/R HBAMAK 4,1304,1935
subcutaneous
guinea pig 		lowest published lethal dose: 1,600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression 		AEPPAE 186,195,1937
subcutaneous
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R ARZNAD 17,214,1967
subcutaneous
rat 		lowest published lethal dose: 1,570 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Cardiac: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		AEPPAE 186,195,1937
subcutaneous
rabbit 		lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1304,1935
unreported route
man 		lowest published lethal dose: 74 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 144,383,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07420;
Number of Industries 3;
Total Number of Facilities 41;
Number of Occupations 3;
Total Number of Employees Exposed 739
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07420;
Number of Industries 4;
Total Number of Facilities 163;
Number of Occupations 7;
Total Number of Employees Exposed 1,907;
Total Number of Female Employees Exposed 1,486


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an analgesic and antipyretic

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data

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