International Chemical Safety Cards CYCLOHEXIMIDE ICSC: 0244 4-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl) 2,6-Piperidinedione C15H23NO4 Molecular mass: 281.35 ICSC #    0244 CAS #     66-81-9 RTECS # MA4375000 UN #        2588 April 11, 1997 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: all extinguishing agents allowed. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE!  •INHALATION Local exhaust or breathing protection. Fresh air, rest.  •SKIN Redness. Pain. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Diarrhoea. Unconsciousness. See Notes. Do not eat, drink, or smoke during work. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert! Do NOT wash away into sewer. Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles). Separated from food and feedstuffs . Well closed. Keep in a well-ventilated room. Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. R: S: UN Hazard Class: 6.1 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 0244 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards CYCLOHEXIMIDE ICSC: 0244 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic and corrosive fumes including nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes and the skin. Exposure may result in death. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Melting point: 119.5-121°C Solubility in water, g/100 ml at 2°C: 2.1 Octanol/water partition coefficient as log Pow: 0.55 ENVIRONMENTAL DATA Avoid release to the environment in circumstances different to normal use. N O T E S Depending on the degree of exposure, periodic medical examination is suggested. Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken. Animal studies have indicated that the substance may be very toxic by ingestion. Hizarocin, Acti-dione, Acti-aid, Naramycin, Naramycin A and Neocycloheximide are trade names. Transport Emergency Card: TEC (R)-61G41a ADDITIONAL INFORMATION ICSC: 0244 CYCLOHEXIMIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.