RTECS:MA4375000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Glutarimide, 3 - (2 - (3,5 - dimethyl - 2 - oxocyclohexyl) - 2 - hydroxyethyl) -

RTECS #: MA4375000

CAS #: 66-81-9

UPDATE: May 2005 MW: 281.39 MF: C₁₅H₂₃NO₄

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Acti - Aid

Actidion

Actidione

Actidione BR

Actidione PM

Actidione TGF

Aktidion (Czech)

beta - (2 - (3,5 - Dimethyl - 2 - oxocyclohexyl) - 2 - hydroxyethyl) glutarimide

3 - (2 - (3,5 - Dimethyl - 2 - oxocyclohexyl) - 2 - hydroxyethyl) glutarimide

Cycloheximide

Naramycin

Naramycin A

NSC - 185

U - 4527

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit 5 mg/24 hour rinse N/R TXCYAC 14,117,1979
skin
rabbit 1 pph/24 hour moderate NTIS PB274-414

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE**
cytogenetic analysis Drosophila melanogaster other cell types 100 mg/L CLDFAT 2,97,1973
cytogenetic analysis human other cell types 100 mg/L EJCAAH 17,173,1981
cytogenetic analysis human lymphocyte 30 mg/L HEREAY 86,107,1977
cytogenetic analysis intraperitoneal
mouse 100 mg/kg FOBLAN 21,60,1975
cytogenetic analysis mouse other cell types 1 痠ol/L IPPABX 22,349,1986
cytogenetic analysis intravenous
rat 20 mg/kg JELJA7 22,205,1973
DNA adduct human other cell types 0.107 mmol/L/6 hour MOPMA3 57,529,2000
DNA damage human other cell types 0.1 mmol/L MAERE* 53,243,2002
DNA damage mouse lymphocyte 50 痠ol/L MUREAV 203,155,1988
DNA damage rat lymphocyte 10 mg/L/4 hour JTSCDR 27,191,2002
DNA inhibition guinea pig lung 10 mg/L PSEBAA 171,109,1982
DNA inhibition hamster lung 5 mg/L PNASA6 73,2396,1976
DNA inhibition hamster fibroblast 1 mg/L JNCIAM 54,431,1975
DNA inhibition human other cell types 100 mg/L BBACAQ 696,15,1982
DNA inhibition human HeLa cell 1 痠ol/L BCPCA6 14,205,1965
DNA inhibition human lung 10 mg/L PSEBAA 171,109,1982
DNA inhibition human other cell types 100 mg/L CNREA8 41,2483,1981
DNA inhibition human other cell types 300 nmol/L CNREA8 44,2421,1984
DNA inhibition intraperitoneal
mouse 333 mg/kg JCLBA3 30,13,1966
DNA inhibition mouse fibroblast 180 痠ol/L JCLBA3 58,410,1973
DNA inhibition other microorganisms 90 痠ol/L MUREAV 85,275,1981
DNA inhibition other microorganisms 10 mg/L CELLB5 5,311,1975
DNA inhibition other microorganisms 100 mg/L CUGED5 5,119,1982
DNA inhibition pig kidney 1 mg/L CYGEDX 12(1),1,1978
DNA inhibition rat other cell types 10 mg/L CELLB5 5,311,1975
DNA inhibition intraperitoneal
rat 1,500 痢/kg RCOCB8 11,311,1975
DNA repair Escherichia coli 50 痢/disc CNREA8 34,1658,1974
unscheduled DNA synthesis mouse fibroblast 10 mg/L CBRPDS 10,455,1986
mutation in microorganisms Euglena gracilis 500 nmol/L (-enzymatic activation step) CYTZAM 9,280,1974
micronucleus test intraperitoneal
mouse 10 mg/kg MUREAV 120,127,1983
micronucleus test parenteral
mouse 50 mg/kg MUREAV 263,203,1991
mutation in mammalian somatic cells mouse lymphocyte 50,600 nmol/L MUTAEX 3,193,1988
morphological transform intraperitoneal
rat 1 mg/kg BIZNAT 99,171,1980
other mutation test systems guinea pig other cell types 50 mg/L CBINA8 38,339,1982
other mutation test systems human HeLa cell 35 痠ol/L BCPCA6 14,205,1965
other mutation test systems intraperitoneal
mouse 333 mg/kg JCLBA3 30,13,1966
other mutation test systems non-mammalian species 1 mmol/L ABILAE 87,43,1976
other mutation test systems other microorganisms 10 mg/L CYTZAM 11,392,1975
other mutation test systems other microorganisms 50 mg/L IJBBBQ 19,285,1982
other mutation test systems pig kidney 1 mg/L CYGEDX 12(1),1,1978
other mutation test systems intraperitoneal
rat 5 mg/kg BCPCA6 18,951,1969
other mutation test systems intraperitoneal
rat 10 mg/kg BIZNAT 99,171,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
hamster lowest published toxic dose: 60 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility PSEBAA 162,170,1979
intraperitoneal
mouse lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 17,41A,1978
intraperitoneal
mouse lowest published toxic dose: 30 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death TJADAB 25,345,1982
intraperitoneal
rat lowest published toxic dose: 1 mg/kg (4 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina INJFA3 27,238,1982
intraperitoneal
rat lowest published toxic dose: 300 痢/kg (13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 23,25,1981
intraperitoneal
rat lowest published toxic dose: 1 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system BJEPA5 51,361,1970
intraperitoneal
rat lowest published toxic dose: 1 mg/kg (18 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BJEPA5 51,361,1970
intraperitoneal
rat lowest published toxic dose: 250 痢/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system FAATDF 4,352,1984
intraperitoneal
rabbit lowest published toxic dose: 5 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility FESTAS 38,238,1982
parenteral
rat lowest published toxic dose: 750 痢/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) PCBRD2 140,13,1983
parenteral
rabbit lowest published toxic dose: 5 痢/kg (1 day pregnant) Reproductive: Effects on fertility: Other measures of fertility ENDOAO 79,858,1966
subcutaneous
mouse lowest published toxic dose: 80 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death PNASA6 67,779,1970
subcutaneous
mouse lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) PNASA6 67,779,1970

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
cat lethal dose (50 percent kill): 4 mg/kg N/R JACSAT 70,1223,1948
intraperitoneal
guinea pig lethal dose (50 percent kill): 60 mg/kg N/R ANTCAO 10,682,1960
intraperitoneal
hamster lowest published lethal dose: 40 mg/kg N/R PSEBAA 162,170,1979
intraperitoneal
mouse lethal dose (50 percent kill): 100 mg/kg N/R CNCRA6 30,9,1963
intraperitoneal
rat lethal dose (50 percent kill): 3,700 痢/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair JPETAB 136,400,1962
intravenous
dog lethal dose (50 percent kill): 1 mg/kg Gastrointestinal: Nausea or vomiting ARZNAD 8,687,1958
intravenous
mouse lethal dose (50 percent kill): 150 mg/kg N/R JACSAT 69,474,1947
intravenous
rat lethal dose (50 percent kill): 2 mg/kg N/R ANTCAO 10,682,1960
intravenous
rat lowest published toxic dose: 5 mg/kg Blood: Changes in bone marrow not included in above

Blood: Changes in spleen JTSCDR 27,191,2002
intravenous
rabbit lethal dose (50 percent kill): 17 mg/kg N/R JACSAT 70,1223,1948
oral
dog lethal dose (50 percent kill): 65 mg/kg N/R PCOC -,292,1966
oral
guinea pig lethal dose (50 percent kill): 65 mg/kg N/R PCOC -,292,1966
oral
monkey lethal dose (50 percent kill): 60 mg/kg N/R GUCHAZ 6,146,1973
oral
mouse lethal dose (50 percent kill): 133 mg/kg N/R UPJOH* 2(6),-,1971
oral
rat lethal dose (50 percent kill): 2 mg/kg N/R UPJOH* 2(6),-,1971
subcutaneous
chicken lowest published lethal dose: 2 mg/kg N/R CBPCBB 66,83,1980
subcutaneous
guinea pig lethal dose (50 percent kill): 60 mg/kg N/R JACSAT 70,1223,1948
subcutaneous
mouse lethal dose (50 percent kill): 160 mg/kg N/R UPJOH* 2(6),-,1971
subcutaneous
rat lethal dose (50 percent kill): 2,500 痢/kg N/R ANTCAO 10,682,1960
subcutaneous
rat lowest published toxic dose: 1.5 mg/kg Behavioral: Alteration of classical conditioning JOETD7 56,45,1997
unreported route
rat lethal dose (50 percent kill): 133 mg/kg N/R YKYUA6 30,397,1979
unreported route
rat lowest published toxic dose: 2 mg/kg Liver: Other changes

Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TXCYAC 191,26,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 400 mg/kg/4 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response DCTODJ 6,341,1983
oral
monkey lowest published toxic dose: 56 mg/kg/7 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in erythrocyte (RBC) count ANTCAO 10,682,1960

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CRTXB2 2,159,1973
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003
TOXICOLOGY REVIEW
TPHSDY 23,130,2002

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,106,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84338;
Number of Industries 3;
Total Number of Facilities 968;
Number of Occupations 6;
Total Number of Employees Exposed 4,439
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84338;
Number of Industries 2;
Total Number of Facilities 234;
Number of Occupations 7;
Total Number of Employees Exposed 3,059;
Total Number of Female Employees Exposed 2,370

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli polA without S9

REFERENCES:
CODEN
REFERENCE

ABILAE Archives de Biologie (1880-1985). (Liege, Belgium) V.1-96(1), 1880-1985.
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CBPCBB Comparative Biochemistry and Physiology, C: Comparative Pharmacology. (Elsevier Science, POB 800, Kidlington, Oxford OX5 1DX, UK) V.50-73, 1975-82. For publisher information, see CBPCEE.
CBRPDS Cell Biology International Reports. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
CELLB5 Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
CLDFAT Cell Differentiation. (Limerick, Ireland) V.1-24, 1972-88.
CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CUGED5 Current Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1979-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
CYTZAM Cytobiologie. (Stuttgart, Fed. Rep. Ger.) V.1-18, 1969-79. For publisher information, see EJCBDN.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8- 1971-
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955-
IPPABX Iugoslavica Physiologica et Pharmacologica Acta. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.1- 1965-
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879-
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962-
JELJA7 Journal of Electron Microscopy. (Japanese Soc. of Electron Microscopy, Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 1953-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
PCOC Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001)
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used on oranges for processing and to inhibit growth of many pathogenic plant fungi

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

SYNONYMS:
Acti - Aid Actidion Actidione Actidione BR Actidione PM Actidione TGF Aktidion (Czech)	beta - (2 - (3,5 - Dimethyl - 2 - oxocyclohexyl) - 2 - hydroxyethyl) glutarimide 3 - (2 - (3,5 - Dimethyl - 2 - oxocyclohexyl) - 2 - hydroxyethyl) glutarimide Cycloheximide Naramycin Naramycin A NSC - 185 U - 4527

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	5 mg/24 hour rinse	N/R	TXCYAC 14,117,1979
skin rabbit	1 pph/24 hour	moderate	NTIS** PB274-414

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	Drosophila melanogaster other cell types	100 mg/L	CLDFAT 2,97,1973
cytogenetic analysis	human other cell types	100 mg/L	EJCAAH 17,173,1981
cytogenetic analysis	human lymphocyte	30 mg/L	HEREAY 86,107,1977
cytogenetic analysis	intraperitoneal mouse	100 mg/kg	FOBLAN 21,60,1975
cytogenetic analysis	mouse other cell types	1 痠ol/L	IPPABX 22,349,1986
cytogenetic analysis	intravenous rat	20 mg/kg	JELJA7 22,205,1973
DNA adduct	human other cell types	0.107 mmol/L/6 hour	MOPMA3 57,529,2000
DNA damage	human other cell types	0.1 mmol/L	MAERE* 53,243,2002
DNA damage	mouse lymphocyte	50 痠ol/L	MUREAV 203,155,1988
DNA damage	rat lymphocyte	10 mg/L/4 hour	JTSCDR 27,191,2002
DNA inhibition	guinea pig lung	10 mg/L	PSEBAA 171,109,1982
DNA inhibition	hamster lung	5 mg/L	PNASA6 73,2396,1976
DNA inhibition	hamster fibroblast	1 mg/L	JNCIAM 54,431,1975
DNA inhibition	human other cell types	100 mg/L	BBACAQ 696,15,1982
DNA inhibition	human HeLa cell	1 痠ol/L	BCPCA6 14,205,1965
DNA inhibition	human lung	10 mg/L	PSEBAA 171,109,1982
DNA inhibition	human other cell types	100 mg/L	CNREA8 41,2483,1981
DNA inhibition	human other cell types	300 nmol/L	CNREA8 44,2421,1984
DNA inhibition	intraperitoneal mouse	333 mg/kg	JCLBA3 30,13,1966
DNA inhibition	mouse fibroblast	180 痠ol/L	JCLBA3 58,410,1973
DNA inhibition	other microorganisms	90 痠ol/L	MUREAV 85,275,1981
DNA inhibition	other microorganisms	10 mg/L	CELLB5 5,311,1975
DNA inhibition	other microorganisms	100 mg/L	CUGED5 5,119,1982
DNA inhibition	pig kidney	1 mg/L	CYGEDX 12(1),1,1978
DNA inhibition	rat other cell types	10 mg/L	CELLB5 5,311,1975
DNA inhibition	intraperitoneal rat	1,500 痢/kg	RCOCB8 11,311,1975
DNA repair	Escherichia coli	50 痢/disc	CNREA8 34,1658,1974
unscheduled DNA synthesis	mouse fibroblast	10 mg/L	CBRPDS 10,455,1986
mutation in microorganisms	Euglena gracilis	500 nmol/L (-enzymatic activation step)	CYTZAM 9,280,1974
micronucleus test	intraperitoneal mouse	10 mg/kg	MUREAV 120,127,1983
micronucleus test	parenteral mouse	50 mg/kg	MUREAV 263,203,1991
mutation in mammalian somatic cells	mouse lymphocyte	50,600 nmol/L	MUTAEX 3,193,1988
morphological transform	intraperitoneal rat	1 mg/kg	BIZNAT 99,171,1980
other mutation test systems	guinea pig other cell types	50 mg/L	CBINA8 38,339,1982
other mutation test systems	human HeLa cell	35 痠ol/L	BCPCA6 14,205,1965
other mutation test systems	intraperitoneal mouse	333 mg/kg	JCLBA3 30,13,1966
other mutation test systems	non-mammalian species	1 mmol/L	ABILAE 87,43,1976
other mutation test systems	other microorganisms	10 mg/L	CYTZAM 11,392,1975
other mutation test systems	other microorganisms	50 mg/L	IJBBBQ 19,285,1982
other mutation test systems	pig kidney	1 mg/L	CYGEDX 12(1),1,1978
other mutation test systems	intraperitoneal rat	5 mg/kg	BCPCA6 18,951,1969
other mutation test systems	intraperitoneal rat	10 mg/kg	BIZNAT 99,171,1980

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal hamster	lowest published toxic dose: 60 mg/kg (1 day prior to copulation)	Reproductive: Effects on fertility: Other measures of fertility	PSEBAA 162,170,1979
intraperitoneal mouse	lowest published toxic dose: 30 mg/kg (10 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TJADAB 17,41A,1978
intraperitoneal mouse	lowest published toxic dose: 30 mg/kg (9 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	TJADAB 25,345,1982
intraperitoneal rat	lowest published toxic dose: 1 mg/kg (4 day pregnant)	Reproductive: Maternal effects: Uterus, cervix, vagina	INJFA3 27,238,1982
intraperitoneal rat	lowest published toxic dose: 300 痢/kg (13 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 23,25,1981
intraperitoneal rat	lowest published toxic dose: 1 mg/kg (15 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Hepatobiliary system	BJEPA5 51,361,1970
intraperitoneal rat	lowest published toxic dose: 1 mg/kg (18 day pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	BJEPA5 51,361,1970
intraperitoneal rat	lowest published toxic dose: 250 痢/kg (10 day pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	FAATDF 4,352,1984
intraperitoneal rabbit	lowest published toxic dose: 5 mg/kg (1 day prior to copulation)	Reproductive: Effects on fertility: Other measures of fertility	FESTAS 38,238,1982
parenteral rat	lowest published toxic dose: 750 痢/kg (18 day pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	PCBRD2 140,13,1983
parenteral rabbit	lowest published toxic dose: 5 痢/kg (1 day pregnant)	Reproductive: Effects on fertility: Other measures of fertility	ENDOAO 79,858,1966
subcutaneous mouse	lowest published toxic dose: 80 mg/kg (11 day pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	PNASA6 67,779,1970
subcutaneous mouse	lowest published toxic dose: 5 mg/kg (11 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	PNASA6 67,779,1970

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal cat	lethal dose (50 percent kill): 4 mg/kg	N/R	JACSAT 70,1223,1948
intraperitoneal guinea pig	lethal dose (50 percent kill): 60 mg/kg	N/R	ANTCAO 10,682,1960
intraperitoneal hamster	lowest published lethal dose: 40 mg/kg	N/R	PSEBAA 162,170,1979
intraperitoneal mouse	lethal dose (50 percent kill): 100 mg/kg	N/R	CNCRA6 30,9,1963
intraperitoneal rat	lethal dose (50 percent kill): 3,700 痢/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Skin and Appendages: Other: Hair	JPETAB 136,400,1962
intravenous dog	lethal dose (50 percent kill): 1 mg/kg	Gastrointestinal: Nausea or vomiting	ARZNAD 8,687,1958
intravenous mouse	lethal dose (50 percent kill): 150 mg/kg	N/R	JACSAT 69,474,1947
intravenous rat	lethal dose (50 percent kill): 2 mg/kg	N/R	ANTCAO 10,682,1960
intravenous rat	lowest published toxic dose: 5 mg/kg	Blood: Changes in bone marrow not included in above Blood: Changes in spleen	JTSCDR 27,191,2002
intravenous rabbit	lethal dose (50 percent kill): 17 mg/kg	N/R	JACSAT 70,1223,1948
oral dog	lethal dose (50 percent kill): 65 mg/kg	N/R	PCOC** -,292,1966
oral guinea pig	lethal dose (50 percent kill): 65 mg/kg	N/R	PCOC** -,292,1966
oral monkey	lethal dose (50 percent kill): 60 mg/kg	N/R	GUCHAZ 6,146,1973
oral mouse	lethal dose (50 percent kill): 133 mg/kg	N/R	UPJOH* 2(6),-,1971
oral rat	lethal dose (50 percent kill): 2 mg/kg	N/R	UPJOH* 2(6),-,1971
subcutaneous chicken	lowest published lethal dose: 2 mg/kg	N/R	CBPCBB 66,83,1980
subcutaneous guinea pig	lethal dose (50 percent kill): 60 mg/kg	N/R	JACSAT 70,1223,1948
subcutaneous mouse	lethal dose (50 percent kill): 160 mg/kg	N/R	UPJOH* 2(6),-,1971
subcutaneous rat	lethal dose (50 percent kill): 2,500 痢/kg	N/R	ANTCAO 10,682,1960
subcutaneous rat	lowest published toxic dose: 1.5 mg/kg	Behavioral: Alteration of classical conditioning	JOETD7 56,45,1997
unreported route rat	lethal dose (50 percent kill): 133 mg/kg	N/R	YKYUA6 30,397,1979
unreported route rat	lowest published toxic dose: 2 mg/kg	Liver: Other changes Cardiac: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 191,26,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 400 mg/kg/4 week- intermittent	Liver: Changes in liver weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response	DCTODJ 6,341,1983
oral monkey	lowest published toxic dose: 56 mg/kg/7 day- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in erythrocyte (RBC) count	ANTCAO 10,682,1960

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CRTXB2 2,159,1973
TOXICOLOGY REVIEW		TOLED5 140-141,53,2003
TOXICOLOGY REVIEW		TPHSDY 23,130,2002

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Cancelled	RBREV* -,106,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 84338; Number of Industries 3; Total Number of Facilities 968; Number of Occupations 6; Total Number of Employees Exposed 4,439
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 84338; Number of Industries 2; Total Number of Facilities 234; Number of Occupations 7; Total Number of Employees Exposed 3,059; Total Number of Female Employees Exposed 2,370

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli polA without S9

REFERENCES:
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ABILAE	Archives de Biologie (1880-1985). (Liege, Belgium) V.1-96(1), 1880-1985.
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BJEPA5	British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
CBINA8	Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
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CBRPDS	Cell Biology International Reports. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
CELLB5	Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
CLDFAT	Cell Differentiation. (Limerick, Ireland) V.1-24, 1972-88.
CNCRA6	Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO.
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CYGEDX	Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
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FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
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FESTAS	Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
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INJFA3	International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955-
IPPABX	Iugoslavica Physiologica et Pharmacologica Acta. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.1- 1965-
JACSAT	Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879-
JCLBA3	Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962-
JELJA7	Journal of Electron Microscopy. (Japanese Soc. of Electron Microscopy, Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 1953-
JNCIAM	Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOETD7	Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTSCDR	Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MAERE*	Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MOPMA3	Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX	Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBRD2	Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
PCOC**	Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PNASA6	Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSEBAA	Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8	Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TJADAB	Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPHSDY	Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UPJOH*	"Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001)
YKYUA6	Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-