International Chemical Safety Cards p-CRESOL ICSC: 0031 4-Hydroxy-1-methylbenzene 4-Methylphenol para-Hydroxytoluene C7H8O / CH3C6H4OH Molecular mass: 108.2 ICSC #    0031 CAS #     106-44-5 RTECS # GO6475000 UN #        2076 EC #         604-004-00-9 October 02, 2000 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Water spray, powder, AFFF, foam, carbon dioxide. EXPLOSION Above 86°C explosive vapour/air mixtures may be formed. Above 86°C use a closed system, ventilation. EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Burning sensation. Sore throat. Cough. Headache. Nausea. Vomiting. Laboured breathing. Shortness of breath. Symptoms may be delayed (see Notes). Local exhaust or breathing protection. Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention.  •SKIN MAY BE ABSORBED! Redness. Pain. Blisters. Skin burns. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Redness. Pain. Severe deep burns. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Nausea. Vomiting. Abdominal pain. Burning sensation. Shock or collapse. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: complete protective clothing including self-contained breathing apparatus). Do NOT let this chemical enter the environment. Separated from strong oxidants, food and feedstuffs . Do not transport with food and feedstuffs. Marine pollutant. Note: C T symbol R: 24/25-34 S: 1/2-36/37/39-45 UN Hazard Class: 6.1 UN Subsidiary Risks: 8 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0031 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards p-CRESOL ICSC: 0031 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS , WITH CHARACTERISTIC ODOUR. TURNS DARK ON EXPOSURE TO AIR AND LIGHT . PHYSICAL DANGERS: CHEMICAL DANGERS: Reacts violently with strong oxidants . OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 ppm (as TWA) (skin) (ACGIH 2000). MAK: class H, 3 (1999) OSHA PEL: TWA 5 ppm (22 mg/m3) skin NIOSH REL: TWA 2.3 ppm (10 mg/m3) NIOSH IDLH: 250 ppm ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of vapour or aerosol may cause lung oedema (see Notes). The substance may cause effects on the central nervous system , cardiovascular system , lungs , kidneys and liver , resulting in central nervous system depression, respiratory failure and tissue lesions . Exposure at high levels may result in lowering of consciousness and death . EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the cardiovascular system and central nervous system . PHYSICAL PROPERTIES Boiling point: 202°C Melting point: 35°C Density: 1.02 g/cm3 Solubility in water, g/100 ml at 25°C: 1.9 Vapour pressure, Pa at 25°C: 15 Relative vapour density (air = 1): 3.7 Flash point: 86°C c.c. Auto-ignition temperature: 559°C Explosive limits, vol% in air: 1.1 at 150°C -? Octanol/water partition coefficient as log Pow: 1.94 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. Transport Emergency Card: TEC (R)-61GTC2-II NFPA Code: H 3; F 2; R 0; ADDITIONAL INFORMATION ICSC: 0031 p-CRESOL (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.