The Registry of Toxic Effects of Chemical Substances

p - Cresol

RTECS #: GO6475000

CAS #: 106-44-5

UPDATE: May 2004 MW: 108.15 MF: C7H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 4 - Cresol
  2. p - Cresylic acid
  3. 1 - Hydroxy - 4 - methylbenzene
  4. p - Hydroxytoluene
  5. 4 - Hydroxytoluene
  6. p - Kresol
  7. p - Methylhydroxybenzene
  8. 1 - Methyl - 4 - hydroxybenzene
  9. p - Methylphenol
  1. 4 - Methylphenol
  2. Paramethyl phenol
  3. RCRA waste number U052
  4. p - Toluol
  5. p - Tolyl alcohol
  6. p - Cresol (ACGIH:OSHA)
  7. p - Oxytoluene
  8. para - Cresol
  9. Phenol, 4 - methyl - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		103 mg severe BIOFX* 5-5/1969
skin
rabbit 		517 mg/24 hour severe BIOFX* 5-5/1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition hamster lung 150 µmol/L CRTOEC 4,151,1991
DNA inhibition human lymphocyte 25 µmol/L RCOCB8 54,133,1986
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 2,280 mg/kg/20 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >710 mg/m3/1 hour N/R BIOFX* 5-5/1969
inhalation
rat 		lethal concentration (50 percent kill): 29 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria 		VCVGK* -,207,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R VCVGK* -,207,1994
intravenous
rabbit 		lowest published lethal dose: 180 mg/kg N/R VCVGK* -,207,1994
oral
mouse 		lethal dose (50 percent kill): 344 mg/kg N/R GTPZAB 18(2),58,1974
oral
mouse 		lethal dose (50 percent kill): 160 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rat 		lethal dose (50 percent kill): 207 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Ulceration or bleeding from stomach 		BIOFX* 5-5/1969
oral
rat 		lethal dose (50 percent kill): 270 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rabbit 		lowest published lethal dose: 620 mg/kg N/R JPETAB 80,233,1944
oral
rabbit 		lethal dose (50 percent kill): 620 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
subcutaneous
cat 		lowest published lethal dose: 80 mg/kg N/R VCVGK* -,207,1994
subcutaneous
dog 		lowest published lethal dose: 200 mg/kg N/R VCVGK* -,207,1994
subcutaneous
frog 		lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
guinea pig 		lowest published lethal dose: 200 mg/kg N/R HBTXAC 5,58,1959
subcutaneous
mouse 		lowest published lethal dose: 150 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rat 		lowest published lethal dose: 500 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rabbit 		lowest published lethal dose: 300 mg/kg N/R HBAMAK 4,1361,1935
skin
rat 		lethal dose (50 percent kill): 750 mg/kg N/R GTPZAB 18(2),58,1974
skin
rat 		lethal dose (50 percent kill): 750 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994
skin
rabbit 		lethal dose (50 percent kill): 301 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Other changes 		BIOFX* 5-5/1969
skin
rabbit 		lethal dose (50 percent kill): 301 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994
unreported route
mouse 		lethal dose (50 percent kill): 160 mg/kg N/R BJCAAI 6,160,1952
unreported route
rat 		lethal dose (50 percent kill): 1,440 mg/kg N/R GTPPAF 8,145,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/40 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
oral
rat 		lowest published toxic dose: 21 gm/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** PB92-174242
oral
rat 		lowest published toxic dose: 33,600 mg/kg/28 day- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** PB92-174242
oral
rat 		lowest published toxic dose: 0.213 mg/kg/213 day- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,208,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) DTLVS* 3,61,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - DENMARK TEA 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (22 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-CRESOL-air 10 hour time-weighted average 2.3 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84266;
Number of Industries 48;
Total Number of Facilities 4,394;
Number of Occupations 34;
Total Number of Employees Exposed 33,253
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84266;
Number of Industries 8;
Total Number of Facilities 1,057;
Number of Occupations 14;
Total Number of Employees Exposed 21,313;
Total Number of Female Employees Exposed 16,798


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a disinfectant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: p-Cresol in urine, 8305
NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546
NTP Toxicity studies, RPT# TOX-09, October 2000


REFERENCES:

CODEN
REFERENCE
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a disinfectant

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Natural Product
   Primary Irritant

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