The Registry of Toxic Effects of Chemical Substances

Zinc, bis (dimethyldithiocarbamato) -

RTECS #: ZH0525000

CAS #: 137-30-4

UPDATE: November 2004 MW: 305.81 MF: C6H12N2S4•Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aaprotect
  2. Aavolex
  3. Aazira
  4. Accelerator L
  5. Aceto ZDED
  6. Alcobam ZM
  7. Bis (N,N - dimetil - ditiocarbammato) di zinco (Italian)
  8. Bis (dimethylcarbamodithioato - S,S') zinc
  9. Bis (dimethyldithiocarbamato) zinc
  10. Bis - dimethyldithiocarbamate de zinc (French)
  11. Carbamic acid, dimethyldithio - , zinc salt (2:1)
  12. Carbazinc
  13. Corona corozate
  14. Corozate
  15. Cuman
  16. Cuman L
  17. Cymate
  18. Dimethylcarbamodithioic acid, zinc complex
  19. Dimethylcarbamodithioic acid, zinc salt
  20. Dimethyldithiocarbamate zinc salt
  21. Dimethyldithiocarbamic acid, zinc salt
  22. Drupina 90
  23. ENT 988
  24. Eptac 1
  25. Fuclasin
  26. Fuclasin Ultra
  27. Fuklasin
  28. Fungostop
  29. Hermat ZDM
  30. Hexazir
  31. Karbam White
  32. Methasan
  33. Methazate
  34. Methyl Ziram
  35. Methyl zimate
  36. Methyl zineb
  37. Mezene
  38. Milbam
  39. Molurame
  40. Mycronil
  41. NCI - C50442
  1. Orchard brand ziram
  2. Pomarsol Z forte
  3. Prodaram
  4. Rhodiacid
  5. Soxinal PZ
  6. Soxinol PZ
  7. Tricarbamix Z
  8. Triscabol
  9. Tsimat
  10. Tsiram (Russian)
  11. USAF P - 2
  12. Vancide MZ - 96
  13. Vulcacure ZM
  14. Vulkacit L
  15. Vulkacite L
  16. Z 75
  17. Z - C spray
  18. ZDMC
  19. Zarlate
  20. Zerlate
  21. Zimate
  22. Zinc N,N - dimethyldithiocarbamate
  23. Zinc bis (dimethyldithiocarbamate)
  24. Zinc bis (dimethyldithiocarbamoyl) disulphide
  25. Zinc bis (dimethylthiocarbamoyl) disulfide
  26. Zinc dimethyldithiocarbamate
  27. Zink - (N,N - dimethyl - dithiocarbamat) (German)
  28. Zink - bis (N,N - dimethyl - dithiocarbamaat) (Dutch)
  29. Zink - bis (N,N - dimethyl - dithiocarbamat) (German)
  30. Ziradin
  31. Ziram
  32. Ziram technical
  33. Ziramvis
  34. Zirasan
  35. Zirasan 90
  36. Zirberk
  37. Zirex 90
  38. Ziride
  39. Zirthane
  40. Zitox


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 25 µg/L SCIEAS 236,933,1987
cytogenetic analysis human lymphocyte 10 nmol/L TXCYAC 4,331,1975
cytogenetic analysis oral
mouse 		1,750 mg/kg/5 day- continuous MUREAV 208,57,1988
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
DNA damage intraperitoneal
rat 		50 mg/kg MUREAV 302,1,1993
DNA inhibition human lymphocyte 1 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 100 µg/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 600 ng/disc MUREAV 40,19,1976
mutation in microorganisms Salmonella typhimurium 5 µg/plate (+/-enzymatic activation step) MUREAV 68,313,1979
micronucleus test human lymphocyte 10 mg/L/21 hour (-enzymatic activation step) MUREAV 497,89,2001
micronucleus test unreported route
mouse 		350 mg/kg/24 hour MUREAV 208,57,1988
mutation in mammalian somatic cells mouse lymphocyte 62,500 ng/L EMMUEG 12,85,1988
morphological transform mouse fibroblast 1 µg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 25 µg/L EMMUEG 13,133,1989
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		500 mg/L SWEHDO 9(Suppl 2),27,1983
specific locus test oral
Drosophila melanogaster 		130 ppm MUREAV 224,161,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		EESADV 7,531,1983
oral
rat 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EESADV 7,531,1983
oral
rat 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system EESADV 7,531,1983
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EESADV 7,531,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 60 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		VPITAR 29,71,1970
oral
mouse 		lowest published toxic dose: 840 mg/kg/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GISAAA 37(9),25,1972
oral
mouse 		lowest published toxic dose: 87,962 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB83-202622
oral
mouse 		lowest published toxic dose: 178,808 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB83-202622
oral
rat 		lowest published toxic dose: 12,978 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-238,1982
oral
rat 		toxic dose : 25,956 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-238,1982
oral
rat 		toxic dose : 13,160 mg/kg/94 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		VPITAR 29,71,1970
oral
rat 		lowest published toxic dose: 7,931 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB83-202622


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >1,056 mg/m3/2 hour Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 12(4),12,1968
inhalation
rat 		lethal concentration (50 percent kill): 26 mg/m3/2 hour N/R NTIS** OTS0540394
intraperitoneal
guinea pig 		lowest published lethal dose: 30 mg/kg Behavioral: Coma JAPMA8 41,662,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 15,500 µg/kg N/R NNGADV 17,S155,1992
intraperitoneal
rat 		lethal dose (50 percent kill): 8,700 µg/kg N/R NNGADV 17,S155,1992
intraperitoneal
rabbit 		lowest published lethal dose: 50 mg/kg Behavioral: Coma JAPMA8 41,662,1952
intravenous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#04886
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
guinea pig 		lethal dose (50 percent kill): 200 mg/kg N/R FATOAO 32,356,1969
oral
mouse 		lethal dose (50 percent kill): 480 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) 		FATOAO 28,230,1965
oral
rat 		lethal dose (50 percent kill): 267 mg/kg N/R EPASR* 8EHQ-1090-1045
oral
rabbit 		lethal dose (50 percent kill): 400 mg/kg N/R PCOC** -,1250,1966
subcutaneous
mouse 		lethal dose (50 percent kill): 309 mg/kg N/R NNGADV 17,S155,1992
subcutaneous
rat 		lethal dose (50 percent kill): 69 mg/kg N/R NNGADV 17,S155,1992
skin
rat 		lethal dose (50 percent kill): >6 gm/kg N/R FMCHA2 -,C329,1991
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R EPASR* 8EHQ-1090-1045
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,400 mg/kg N/R 30ZDA9 -,213,1971
unreported route
rat 		lethal dose (50 percent kill): 1,230 mg/kg N/R EQSSDX 3,618,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/4 hour/17 week- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		GTPZAB 12(4),12,1968
oral
dog 		lowest published toxic dose: 9,125 mg/kg/1 year- continuous Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 118,174,1956
oral
dog 		lowest published toxic dose: 28 mg/kg/4 week- continuous Gastrointestinal: Hypermotility, diarrhea NNGADV 17,S155,1992
oral
dog 		lowest published toxic dose: 3,640 mg/kg/2 year- continuous Gastrointestinal: Hypermotility, diarrhea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NNGADV 17,S155,1992
oral
mouse 		lowest published toxic dose: 16,800 mg/kg/14 day- continuous Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-238,1983
oral
mouse 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-238,1983
oral
mouse 		lowest published toxic dose: 141,316 mg/kg/103 week- intermittent Liver: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB83-202622
oral
rat 		lowest published toxic dose: 22,750 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-238,1983
oral
rat 		lowest published toxic dose: 80,080 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight 		NNGADV 17,S155,1992
oral
rat 		lowest published toxic dose: 45 gm/kg/30 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPMA8 41,662,1952
oral
rat 		lowest published toxic dose: 770 mg/kg/4 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NNGADV 17,S155,1992
oral
rat 		lowest published toxic dose: 4,368 mg/kg/104 week- continuous Nutritional and Gross Metabolic: Changes in: Ca TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 10.9 gm/kg/26 week- continuous Blood: Changes in erythrocyte (RBC) count TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 54.6 gm/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 327.6 gm/kg/78 week- continuous Musculoskeletal: Other changes TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 436.8 gm/kg/104 week- continuous Peripheral Nerve and Sensation: Structural change in nerve or sheath TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 2,184 mg/kg/52 week- continuous Blood: Changes in erythrocyte (RBC) count TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 109.2 gm/kg/26 week- continuous Nutritional and Gross Metabolic: Changes in: Ca TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 218.4 gm/kg/52 week- continuous Endocrine: Changes in thyroid weight TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 436.8 gm/kg/104 week- continuous Peripheral Nerve and Sensation: Structural change in nerve or sheath

Musculoskeletal: Other changes 		TXCYAC 54,45,1989
oral
rat 		lowest published toxic dose: 18,746 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB83-202622


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 53,423,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,259,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,259,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,423,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,423,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,174,1998
Occupational Exposure Limit - SWEDEN NGV 1 mg/m3, KTV 2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80305;
Number of Industries 5;
Total Number of Facilities 267;
Number of Occupations 27;
Total Number of Employees Exposed 3,838
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80305;
Number of Industries 20;
Total Number of Facilities 2,044;
Number of Occupations 23;
Total Number of Employees Exposed 34,594;
Total Number of Female Employees Exposed 5,542


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fungicide, as an accelerator or promoter in the rubber-processing industry
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8821;8EHQ-0892-8916
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8918
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-

Used as a fungicide, as an accelerator or promoter in the rubber-processing industry

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Hormone

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