The Registry of Toxic Effects of Chemical Substances

Zinc, (ethylenebis (dithiocarbamato) ) -

RTECS #: ZH3325000

CAS #: 12122-67-7

UPDATE: February 2005 MW: 275.73 MF: C4H6N2S4•Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aspor
  2. Asporum
  3. Ethylenebis (dithiocarbamato) zinc
  4. Ethylenebis (dithiocarbamic acid) , zinc salt
  5. Novosir N
  6. Novozin N 50
  7. Novozir
  8. Novozir N
  9. Novozir N 50
  10. Pamosol 2 forte
  11. Tritoftorol
  12. Tsineb (Russian)
  13. Zineb
  14. Zineb 75
  15. Zineb 75 WP
  16. Aaphytora
  17. Bercema
  18. Blightox
  19. Blizene
  20. Carbadine
  21. CHEM zineb
  22. Cineb
  23. Crittox
  24. Cynkotox
  25. Daisen
  26. Devizeb
  27. Dipher
  28. Discon - Z
  29. Dithane 65
  30. Dithane Z
  31. Dithane Z - 78
  32. Ditiamina
  1. ENT 14,874
  2. ( (1,2 - Ethanediylbis (carbamodithioato) ) (2 - ) ) zinc
  3. 1,2 - Ethanediylbis (carbamodithioato) (2 - ) - S,S' - zinc
  4. 1,2 - Ethanediylbiscarbamodithioic acid, zinc complex
  5. Hexathane
  6. Kupratsin
  7. Kypzin
  8. Lirotan
  9. Lonacol
  10. Micide
  11. Parzate C
  12. Parzate zineb
  13. Perosin
  14. Perosin 75B
  15. Perozin
  16. Perozine
  17. Phytox
  18. Polyram Z
  19. Sperlox - Z
  20. Tanazon
  21. Thiodow
  22. Tiazin
  23. Tiezene
  24. Zebenide
  25. Zebtox
  26. Zidan
  27. Zinc ethylenebisdithiocarbamate
  28. Zinc ethylene - 1,2 - bisdithiocarbamate
  29. Zineb 80
  30. Zink - (N,N' - aethylen - bis (dithiocarbamat) ) (German)
  31. Zinosan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L/24 hour MUREAV 536,121,2003
cytogenetic analysis inhalation
human 		500 µg/m3/7 hour/3 year- intermittent GTPZAB 20(12),26,1976
cytogenetic analysis human other cell types 0.1 mg/L/48 hour MUTAEX 16,487,2001
cytogenetic analysis human HeLa cell 5 mg/L/24 hour MUREAV 536,121,2003
cytogenetic analysis human fibroblast 1 mg/L/24 hour MUREAV 536,121,2003
cytogenetic analysis oral
mouse 		10 mg/kg GISAAA 45(1),80,1980
DNA damage hamster ovary 1 mg/L/80 minute MUREAV 514,201,2002
DNA damage intraperitoneal
rat 		50 mg/kg MUREAV 302,1,1993
DNA inhibition human lymphocyte 10 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 1 mg/L ARTODN 45,101,1980
mutation in microorganisms Bacillus subtilis 1 nmol/plate (-enzymatic activation step) MSERDS 5,93,1981
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
micronucleus test human lymphocyte 25 mg/L/72 hour EMMUEG 40,57,2002
gene conversion and mitotic recombination Saccharomyes cerevisiae 60 ppm NTIS** PB85-193761
other mutation test systems human fibroblast 10 µg/kg GTPZAB 17(3),32,1973
sister chromatid exchange hamster ovary 10 mg/L/36 hour MUREAV 514,201,2002
sister chromatid exchange human lymphocyte 10 mg/L GESKAC 12,118,1979
sister chromatid exchange human other cell types 50 mg/L/72 hour MUTAEX 16,487,2001
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		50 ppm/4 day- continuous MUREAV 206,25,1988
specific locus test oral
Drosophila melanogaster 		50 ppm/4 day- continuous MUREAV 206,25,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) GISAAA 37(8),42,1972
oral
rat 		lowest published toxic dose: 4 gm/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTXAV 11,239,1973
oral
rat 		lowest published toxic dose: 4 gm/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death 		FCTXAV 11,239,1973
oral
rat 		lowest published toxic dose: 8 gm/kg (9 day pregnant) Reproductive: Effects on fertility: Other measures of fertility EKMMA8 10,226,1971
oral
rat 		lowest published toxic dose: 4 gm/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear EKMMA8 10,226,1971
oral
rat 		lowest published toxic dose: 8 mg/kg (16 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TOERD9 3,279,1981
oral
rat 		lowest published toxic dose: 28 gm/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB80-181175


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 80 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		VPITAR 29,71,1970
intraperitoneal
mouse 		lowest published toxic dose: 2,600 mg/kg/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		VRDEA5 (9),100,1966
intraperitoneal
mouse 		lowest published toxic dose: 1,760 mg/kg (11-21 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors 		VPITAR 30,49,1971
oral
mouse 		lowest published toxic dose: 7,800 mg/kg/5 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GISAAA 37(9),25,1972
oral
rat 		lowest published toxic dose: 53,580 mg/kg/94 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors 		VPITAR 29,71,1970
oral
rat 		lowest published toxic dose: 273 gm/kg/2.5 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors 		JTSCDR 4,290,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 800 mg/m3/4 hour N/R 85GMAT -,121,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,940 mg/kg N/R 85GMAT -,121,1982
intraperitoneal
rat 		lowest published toxic dose: 70 mg/kg Endocrine: Other changes ATSUDG Suppl.8,253,1985
oral
human 		lowest published lethal dose: 5 gm/kg N/R 85JFAN A420,1984
oral
mouse 		lethal dose (50 percent kill): 7,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia 		JTEHD6 4,93,1978
oral
rat 		lethal dose (50 percent kill): 1,850 mg/kg Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 31(10),25,1966
oral
rabbit 		lethal dose (50 percent kill): 4,450 mg/kg N/R 85GMAT -,121,1982
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R TXAPA9 14,515,1969
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,350 mg/kg N/R GISAAA 45(5),29,1980
unreported route
rat 		lethal dose (50 percent kill): 1,850 mg/kg N/R EQSSDX 3,618,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cattle 		lowest published toxic dose: 10,800 mg/kg/39 week- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Changes in testicular weight 		ATSUDG 12,107,1988
oral
rat 		lowest published toxic dose: 14 gm/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** PB80-181175
oral
rat 		lowest published toxic dose: 30 gm/kg/30 day- intermittent Endocrine: Other changes

Endocrine: Changes in pituitary weight

Endocrine: Changes in thyroid weight 		BECTA6 22,208,1979
oral
rat 		lowest published toxic dose: 364 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Other changes

Endocrine: Thyroid weight (goiter)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 109,159,1953
oral
rat 		lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Endocrine: Hypoglycemia BECTA6 56,847,1996
oral
rabbit 		lowest published toxic dose: 18,200 mg/kg/26 week- intermittent Gastrointestinal: Alteration in gastric secretion

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 31(10),25,1966
oral
rabbit 		lowest published toxic dose: 6,231 mg/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight 		VHTODE 37,137,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,245,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,245,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
CNDQA8 14,49,1979
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,218,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83787;
Number of Industries 1;
Total Number of Facilities 12;
Number of Occupations 1;
Total Number of Employees Exposed 72
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83787;
Number of Industries 1;
Total Number of Facilities 291;
Number of Occupations 1;
Total Number of Employees Exposed 3,205


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as a fungicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #107


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GESKAC Genetika i Selektsiya. Genetics and Plant Breeding. (Izdatelstvo na Bulgarskata Akademiya na Naukite, ul. Akad. G. Bonchev, 1113 Sofia, Bulgaria) V.1- 1968-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MMAPAP Mycopathologia et Mycologia Applicata. (The Hague, Netherlands) V.5-54(4), 1950-74. For publisher information, see MYCPAH.
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918-

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 142-14-3
ALT CAS #: 14039-25-9
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