The Registry of Toxic Effects of Chemical Substances

Zinc

RTECS #: ZG8600000

CAS #: 7440-66-6

UPDATE: May 2005 MW: 65.37 MF: Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Blue powder
  2. Granular zinc
  3. LS 2
  4. LS 6
  1. Merrillite
  2. Rheinzink
  3. Zinc powder
  4. Zinc dust


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		300 µg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 12.600 mg/kg/46 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Facilitates action of known carcinogens 		CALEDQ 143,63,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 124 mg/m3/50 minute Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating 		AHYGAJ 72,358,1910
intratracheal
rat 		lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		VCVN1* -,151,1988
oral
duck 		lowest published lethal dose: 388 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia

Blood: Changes in leukocyte (WBC) count 		JWIDAW 36,111,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
woman 		lowest published toxic concentration: 2.4 mg/m3/5 year- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVN1* -,154,1988
oral
woman 		lowest published toxic dose: 70 mg/kg/10 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 72,143,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
QURBAW 7,75,1974
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
CREOH* 42,93,2002
TOXICOLOGY REVIEW
MAERE* 51,247,2001
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,346,1998
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0146;
Number of Industries 2;
Total Number of Facilities 44;
Number of Occupations 1;
Total Number of Employees Exposed 324
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 77115;
Number of Industries 120;
Total Number of Facilities 9,450;
Number of Occupations 90;
Total Number of Employees Exposed 118,548
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4242;
Number of Industries 46;
Total Number of Facilities 3,278;
Number of Occupations 47;
Total Number of Employees Exposed 79,920;
Total Number of Female Employees Exposed 7,874
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5913;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 2;
Total Number of Employees Exposed 269;
Total Number of Female Employees Exposed 22
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5990;
Number of Industries 2;
Total Number of Facilities 42;
Number of Occupations 3;
Total Number of Employees Exposed 1,007;
Total Number of Female Employees Exposed 321
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5991;
Number of Industries 8;
Total Number of Facilities 177;
Number of Occupations 18;
Total Number of Employees Exposed 10,589;
Total Number of Female Employees Exposed 3,273
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 77115;
Number of Industries 211;
Total Number of Facilities 23,711;
Number of Occupations 133;
Total Number of Employees Exposed 320,917;
Total Number of Female Employees Exposed 34,194


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100236/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in copper alloys, galvanizing, light alloys, rolled and wire drawn zinc, sheet products
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Zinc and compounds as Zn, 7030
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID125G


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100, 1883-1928. For publisher information, see ZHPMAT.
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
JWIDAW Journal of Wildlife Diseases. (Wildlife Disease Assoc., POB 886, Ames, IA 50010) V.6- 1970-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in copper alloys, galvanizing, light alloys, rolled and wire drawn zinc, sheet products

NIOSH PROFILE (HEAVY METAL GREASES AND SOAPS), SRI, 2/77

NIOSH PROFILE (PRINTING INDUSTRY), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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