The Registry of Toxic Effects of Chemical Substances
2,4 - Xylidine, N,N' - (methyliminodimethylidyne) bis - |
UPDATE: May 2005 | MW: 293.45 | MF: C19H23N3 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 887 mg/kg (84 day male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TOLED5 138,253,2003 |
oral mouse | lowest published toxic dose: 455 mg/kg (84 day male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TOLED5 138,253,2003 |
oral rat | lowest published toxic dose: 140 mg/kg (7 day prior to copulation) | Reproductive: Effects on newborn: Delayed effects | NETEEC 16,65,1994 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 65 gm/m3/6 hour | N/R | DEVEAA 33,66,1979 |
intramuscular rat | lowest published lethal dose: 250 mg/kg |
Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Blood: Hemorrhage Skin: After systemic exposure: Dermatitis, other | VHTODE 41,355,1999 |
intraperitoneal mouse | lethal dose : 600 mg/kg | N/R | TXAPA9 93,319,1988 |
intraperitoneal mouse | lowest published toxic dose: 150 mg/kg | Brain and Coverings: Other degenerative changes | TXAPA9 93,319,1988 |
intraperitoneal rat | lethal dose (50 percent kill): 800 mg/kg | N/R | DEVEAA 33,66,1979 |
intraperitoneal rat | lowest published toxic dose: 40 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | LSPPAT 23,2509,1978 |
intraperitoneal rat | lowest published toxic dose: 80 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | LSPPAT 23,2509,1978 |
oral duck | lethal dose (50 percent kill): 7 gm/kg | N/R | PEMNDP 9,28,1991 |
oral dog | lethal dose (50 percent kill): 100 mg/kg | N/R | SPEADM 78-1,22,1978 |
oral guinea pig | lethal dose (50 percent kill): >400 mg/kg | N/R | DEVEAA 33,66,1979 |
oral man | lowest published toxic dose: 3,571 mg/kg |
Behavioral: Ataxia Behavioral: Coma Cardiac: Pulse rate decreased with fall in BP | HETOEA 16,600,1997 |
oral mouse | lethal dose (50 percent kill): 1,085 mg/kg | N/R | MTPEEI (4),36,1995 |
oral quail | lethal dose (50 percent kill): 788 mg/kg | N/R | FMCHA2 -,C20,1991 |
oral rat | lethal dose (50 percent kill): 400 mg/kg | N/R | 85KYAH 11,80,1989 |
oral rabbit | lethal dose (50 percent kill): >100 mg/kg | N/R | DEVEAA 33,66,1979 |
oral woman | lowest published lethal dose: 200 無/kg |
Brain and Coverings: Other degenerative changes Cardiac: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | AJEMEN 6,510,1988 |
skin rat | lethal dose (50 percent kill): >1,600 mg/kg | N/R | SPEADM 78-1,22,1978 |
skin rabbit | lethal dose (50 percent kill): >200 mg/kg | N/R | DEVEAA 33,66,1979 |
unreported route rat | lethal dose (50 percent kill): 600 mg/kg | N/R | JJTOEX 2,289,1989 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal rat | lowest published toxic dose: 150 mg/kg/3 day- intermittent | Behavioral: Alteration of operant conditioning | FAATDF 9,131,1987 |
intraperitoneal rat | lowest published toxic dose: 30 mg/kg/3 day- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 42,1785,2004 |
intraperitoneal rat | lowest published toxic dose: 75 mg/kg/3 day- intermittent |
Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data: Changes in uterine weight | FCTOD7 42,1785,2004 |
intraperitoneal rat | lowest published toxic dose: 150 mg/kg/3 day- intermittent |
Lung, Thorax, or Respiration: Changes in lung weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 42,1785,2004 |
oral mouse | lowest published toxic dose: 455.28 mg/kg/12 week- continuous |
Behavioral: Fluid intake Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | TOLED5 138,253,2003 |
oral mouse | lowest published toxic dose: 887.04 mg/kg/12 week- continuous |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TOLED5 138,253,2003 |
oral mouse | lowest published toxic dose: 1,712.76 mg/kg/12 week- continuous | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOLED5 138,253,2003 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| TOLED5 142,207,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: RED Completed | RBREV* -,85,1998 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
N/R | N/R | N/R |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
On EPA IRIS database |
REFERENCES: | |
CODEN |
REFERENCE |
85KYAH | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 |
AJEMEN | American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- |
DEVEAA | Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- |
FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
FCTOD7 | Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
FMCHA2 | Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) |
HETOEA | Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- |
JJTOEX | Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- |
LSPPAT | Life Sciences, Part 1: Physiology and Pharmacology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK. |
MTPEEI | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993- |
NETEEC | Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- |
PEMNDP | Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
SPEADM | Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
VHTODE | Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- |