The Registry of Toxic Effects of Chemical Substances

Xylidine

RTECS #: ZE8575000

CAS #: 1300-73-8

UPDATE: November 2004 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Aminodimethylbenzene
  2. Dimethylaminobenzene (OSHA)
  3. Xilidine (Italian)
  1. Xylidine (ACGIH:OSHA)
  2. Xylidine (mixed isomers)
  3. Xylidinen (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
cat 		lowest published lethal dose: 120 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JIHTAB 31,1,1949
intravenous
rabbit 		lowest published lethal dose: 240 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JIHTAB 31,1,1949
oral
rat 		lowest published lethal dose: 610 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JIHTAB 31,1,1949
oral
rabbit 		lethal dose (50 percent kill): 600 mg/kg N/R 34ZIAG -,637,1969
skin
mouse 		lethal dose (50 percent kill): 1,670 mg/kg N/R GTPZAB 20(10),5,1976
skin
rat 		lethal dose (50 percent kill): 2 gm/kg N/R GTPZAB 20(10),5,1976
skin
rabbit 		lethal dose (50 percent kill): 1,500 mg/kg N/R GTPZAB 20(10),5,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (25 mg/m3) (skin) DTLVS* 3,282,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (9.9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.5 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (435 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (10 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (25 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (10 mg/m3), short term exposure limit 10 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO XYLIDINE-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76910;
Number of Industries 5;
Total Number of Facilities 110;
Number of Occupations 7;
Total Number of Employees Exposed 1,754
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76910;
Number of Industries 8;
Total Number of Facilities 432;
Number of Occupations 11;
Total Number of Employees Exposed 2,319;
Total Number of Female Employees Exposed 316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a raw material in manufacture of dyes, pharmaceuticals and other organic compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a raw material in manufacture of dyes, pharmaceuticals and other organic compounds

NIOSH PROFILE (ARENES), SRI, 2/77

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