RTECS:ZE6475000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

3,5 - Xylenol

RTECS #: ZE6475000

CAS #: 108-68-9

UPDATE: November 2003 MW: 122.18 MF: C₈H₁₀O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

3,5 - Dimethylphenol

Phenol, 3,5 - dimethyl - (9CI)

4,4' - Methylenediphenyl diisocyanate

1,3,5 - Xylenol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 250 痢 severe AJOPAA 29,1363,1946

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 9 mg/m³/6 hour (6-15 day pregnant) Reproductive: Other effects on female NTIS OTS0557594

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
mouse lowest published toxic dose: 4,000 mg/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors CNREA8 19,413,1959

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
rat lethal concentration : >4 mg/m³ N/R GTPZAB 23(10),52,1979
inhalation
rat lowest published toxic concentration: 4 mg/m³ Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,204,1994
intraperitoneal
mouse lethal dose (50 percent kill): 156 mg/kg N/R JMCMAR 18,868,1975
oral
mouse lethal dose (50 percent kill): 477 mg/kg Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea HYSAAV 33(7-9),329,1968
oral
mouse lethal dose (50 percent kill): 477,000 mg/m³ N/R VCVGK* -,205,1994
oral
rat lethal dose (50 percent kill): 608 mg/kg N/R GTPPAF 8,145,1972
oral
rat lethal dose (50 percent kill): 608,000 mg/m³ N/R VCVGK* -,205,1994
oral
rabbit lethal dose (50 percent kill): 1,313 mg/kg Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea HYSAAV 33(7-9),329,1968
oral
rabbit lethal dose (50 percent kill): 1,313,000 mg/m³ N/R VCVGK* -,205,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1583;
Number of Industries 2;
Total Number of Facilities 61;
Number of Occupations 2;
Total Number of Employees Exposed 136;
Total Number of Female Employees Exposed 56

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as antioxidant, solvent, plasticizer, wetting agent and in pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as antioxidant, solvent, plasticizer, wetting agent and in pharmaceuticals

NIOSH PROFILE (XYLENOLS), SRC, 3/81

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 9 mg/m³/6 hour (6-15 day pregnant)	Reproductive: Other effects on female	NTIS** OTS0557594

SYNONYMS:
3,5 - Dimethylphenol Phenol, 3,5 - dimethyl - (9CI)	4,4' - Methylenediphenyl diisocyanate 1,3,5 - Xylenol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	250 痢	severe	AJOPAA 29,1363,1946

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin mouse	lowest published toxic dose: 4,000 mg/kg/20 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	CNREA8 19,413,1959

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration : >4 mg/m³	N/R	GTPZAB 23(10),52,1979
inhalation rat	lowest published toxic concentration: 4 mg/m³	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	VCVGK* -,204,1994
intraperitoneal mouse	lethal dose (50 percent kill): 156 mg/kg	N/R	JMCMAR 18,868,1975
oral mouse	lethal dose (50 percent kill): 477 mg/kg	Behavioral: Ataxia Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	HYSAAV 33(7-9),329,1968
oral mouse	lethal dose (50 percent kill): 477,000 mg/m³	N/R	VCVGK* -,205,1994
oral rat	lethal dose (50 percent kill): 608 mg/kg	N/R	GTPPAF 8,145,1972
oral rat	lethal dose (50 percent kill): 608,000 mg/m³	N/R	VCVGK* -,205,1994
oral rabbit	lethal dose (50 percent kill): 1,313 mg/kg	Behavioral: Ataxia Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	HYSAAV 33(7-9),329,1968
oral rabbit	lethal dose (50 percent kill): 1,313,000 mg/m³	N/R	VCVGK* -,205,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X1583; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 2; Total Number of Employees Exposed 136; Total Number of Female Employees Exposed 56

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as antioxidant, solvent, plasticizer, wetting agent and in pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AJOPAA	American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CNREA8	Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
GTPPAF	Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
GTPZAB	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV	Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JMCMAR	Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.