The Registry of Toxic Effects of Chemical Substances

2,4 - Xylenol

RTECS #: ZE5600000

CAS #: 105-67-9

UPDATE: November 2003 MW: 122.18 MF: C8H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 2,4 - dimethylbenzene
  2. 2,4 - Dimethylphenol
  3. 4,6 - Dimethylphenol
  4. Phenol, 2,4 - dimethyl - (9CI)
  1. RCRA waste number U101
  2. Xylenol
  3. m - Xylenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 16 gm/kg/39 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >30 mg/m3 N/R GTPZAB 23(10),52,1979
inhalation
rat 		lowest published toxic concentration: 26 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,204,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 183 mg/kg N/R JMCMAR 18,868,1975
intravenous
mouse 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Sleep JMCMAR 23,1350,1980
oral
mouse 		lethal dose (50 percent kill): 809 mg/kg N/R TOBHB* VI:137,1,1995
oral
rat 		lethal dose (50 percent kill): 3,200 mg/kg N/R TOBHB* VI:137,1,1995
skin
rat 		lethal dose (50 percent kill): 1,040 mg/kg N/R TOBHB* VI:137,1,1995


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 23 mg/m3/4 hour/30 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,205,1994
oral
rat 		lowest published toxic dose: 6 gm/kg/10 day- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count 		DCTODJ 16,351,1993
oral
rat 		lowest published toxic dose: 48,600 mg/kg/90 day- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DCTODJ 16,351,1993
oral
rat 		lowest published toxic dose: 8,400 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight 		TOBHB* VI:137,1,1995
oral
rat 		lowest published toxic dose: 8,400 mg/kg/4 week- intermittent Vascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Liver: Changes in liver weight 		TOBHB* VI:137,1,1995
oral
rat 		lowest published toxic dose: 2,800 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight TOBHB* VI:137,1,1995
oral
rat 		lowest published toxic dose: 15,120 mg/kg/12 week- intermittent Gastrointestinal: Gastritis TOBHB* VI:137,1,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,345,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2332;
Number of Industries 7;
Total Number of Facilities 736;
Number of Occupations 8;
Total Number of Employees Exposed 12,254;
Total Number of Female Employees Exposed 786


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in pharmaceuticals, solvents and plasticizers and as antioxidant in gas and oils
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOBHB* TA:Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in pharmaceuticals, solvents and plasticizers and as antioxidant in gas and oils

NIOSH PROFILE (XYLENOLS), SRC, 3/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug

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