The Registry of Toxic Effects of Chemical Substances

Vondozeb

RTECS #: ZB3200000

CAS #: 8018-01-7

UPDATE: May 2005 MW: 541.03 MF: C4H6MnN2S4•C4H6N2S4Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Agrox 16D
  2. Novozir MN 80
  3. Othane M 45
  4. Tritogol MZ
  5. Carbamic acid, ethylenebis (dithio - , manganese zinc complex (8CI)
  6. Carmazine
  7. Dithane M 45
  8. Dithane S 60
  9. Dithane SPC
  10. Dithane ultra
  11. F 2966
  12. Fore
  13. Green - daisen M
  14. Karamate
  15. Kascade
  16. Mancofol
  17. Mancomix
  18. Mancozeb
  19. Mancozi
  1. Maneb - zinc
  2. Maneb - zineb - komplex (German)
  3. Maneb - zineb - mischkomplex (German)
  4. Mangan - zink - aethylendiamin - bis - dithio - carbamat (German)
  5. Manoseb
  6. Manzate 200
  7. Manzeb
  8. Marzidan
  9. Marzin
  10. Manzin 80
  11. Nemispor
  12. Penncozeb
  13. Tanzeo M45
  14. Thane M45
  15. Zimanat
  16. Ziman - Dithane
  17. Zineb - maneb mixt.
  18. Zimaneb


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 4 mg/L MUREAV 116,341,1983
cytogenetic analysis unreported route
mouse 		100 mg/kg TGANAK 16(1),45,1982
cytogenetic analysis intraperitoneal
rat 		2,500 µg/kg MUREAV 116,341,1983
cytogenetic analysis oral
rat 		476 mg/kg/40 week- intermittent MUREAV 116,341,1983
unscheduled DNA synthesis human fibroblast 10 mg/L NTIS** PB85-193761
unscheduled DNA synthesis skin
mouse 		100 mg/kg CRNGDP 13,131,1992
mutation in microorganisms Aspergillus nidulans 12 mg/L (-enzymatic activation step) MUREAV 176,29,1987
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976
gene conversion and mitotic recombination Saccharomyes cerevisiae 50 ppm NTIS** PB85-193761


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/6 hour (6-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 84,355,1986
oral
rat 		lowest published toxic dose: 1,320 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		TJADAB 14,171,1976
oral
rat 		lowest published toxic dose: 1,320 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis 		TJADAB 14,171,1976
unreported route
rat 		lowest published toxic dose: 2,500 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		KHZDAN 27,524,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 17,700 mg/kg/60 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		CALEDQ 53,191,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 5 gm/kg N/R 85JFAN A251,1986
skin
rat 		lethal dose (50 percent kill): >10 gm/kg N/R 85JFAN A251,1986
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,530,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,000 mg/kg/5 day- intermittent Behavioral: Alteration of classical conditioning ETOPFR 15,9,2003
oral
mouse 		lowest published toxic dose: 8,000 mg/kg/10 day- intermittent Endocrine: Changes in thymus weight ETOPFR 15,9,2003
oral
mouse 		lowest published toxic dose: 16 gm/kg/20 day- intermittent Related to Chronic Data: Changes in testicular weight

Liver: Changes in liver weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		ETOPFR 15,9,2003
oral
mouse 		lowest published toxic dose: 24 gm/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight 		ETOPFR 15,9,2003
oral
rat 		lowest published toxic dose: 6,300 mg/kg/12 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FCTOD7 27,531,1989
oral
rat 		lowest published toxic dose: 45 gm/kg/90 day- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		IJEBA6 31,564,1993
oral
rat 		lowest published toxic dose: 5,250 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport 		IJEBA6 29,943,1991
oral
rat 		lowest published toxic dose: 180 gm/kg/1 year- intermittent Gastrointestinal: Hypermotility, diarrhea

Endocrine: Changes in thyroid weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JJATDK 17,369,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,129,1998
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg(Mn)/m3, short term exposure limit 0.6 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 1 mg(Mn)/m3, KTV 2.5 mg(Mn)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 2.5 mg(Mn)/m3, KTV 5 mg(Mn)/m3 (total dust), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
Used as a fungicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 8064-36-6
ALT CAS #: 8065-67-6
ALT CAS #: 12001-34-2
ALT CAS #: 62712-14-5
ALT CAS #: 84070-12-2
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