The Registry of Toxic Effects of Chemical Substances

Vinyl fluoride

RTECS #: YZ7351000

CAS #: 75-02-5

UPDATE: May 2005 MW: 46.05 MF: C2H3F


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ethene, fluoro -
  2. Ethylene, fluoro - (8CI)
  3. Fluoroethene
  4. Fluoroethylene
  1. Fluoroethylene (IUPAC)
  2. Monofluoroethene
  3. Monofluoroethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test inhalation
mouse 		19,100 ppm/6 hour- continuous EMMUEG 19(Suppl 20),5,1992
morphological transform inhalation
rat 		2,000 ppm/14 week- intermittent ARTODN 47,71,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 25 ppm/6 hour/1.5 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** OTS0538078
inhalation
rat 		lowest published toxic concentration: 2,500 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		NTIS** OTS0538078


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >80 pph/12.5 hour Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		AIHOAX 2(3),335,1950
inhalation
rat 		lethal concentration (50 percent kill): 1,600,000 mg/m3/4 hour N/R VCVGH* -,286,1990
inhalation
rat 		lowest published toxic concentration: 864 mg/m3/30 minute Behavioral: General anesthetic VCVGH* -,286,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 20,000 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0522820
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/6 hour/13 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0522820


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,467,1995
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 39,147,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,147,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,467,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 63,467,1995


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL FLUORIDE-air use 29 Code of Federal Regulations (CFR) 1910.1017 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chemical and polymer intermediate
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AIHOAX Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as chemical and polymer intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen

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