The Registry of Toxic Effects of Chemical Substances

Vanadium pentoxide (fume)

RTECS #: YW2460000

CAS #: 1314-62-1

UPDATE: May 2004 MW: 181.88 MF: O5V2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. OTHER MULTIPLE DOSE DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. RCRA waste number P120
  2. Vanadium (OSHA)
  1. Vanadium pentoxide, fume (ACGIH)
  2. Vanadium pentoxide, nonfused form, fume (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 27 µg/m3/24 hour/70 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 31(7),8,1966
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/24 hour/17 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase 		GISAAA 46(2),17,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(V2O5)/m3 (R) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
85DHAX V,46,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg/m3 (fume) DTLVS* 3,275,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(V2O5)/m3, fume CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(V2O5)/m3, fume CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(V2O5)/m3, fume CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(V2O5)/m3, fume CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.5 mg(V2O5)/m3, dust CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 0.05 mg/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(V2O5)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.2 mg(V)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (175 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(V)/m3, total inhalable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.04 mg(V)/m3, fume and respirable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-air ceiling concentration 0.05 mg/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76210;
Number of Industries 7;
Total Number of Facilities 333;
Number of Occupations 12;
Total Number of Employees Exposed 2,562
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76210;
Number of Industries 6;
Total Number of Facilities 67;
Number of Occupations 17;
Total Number of Employees Exposed 4,468;
Total Number of Female Employees Exposed 541


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vanadium oxides, 7504
NIOSH Analytical Method, 1996: Elements by ICP, 7300
NTP Carcinogenesis studies; on test (two year studies), October 2000
OSHA ANALYTICAL METHOD #ID-185


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

RTECS Compound Description:
   Tumorigen

Click Here for Additional Information about RTECS