The Registry of Toxic Effects of Chemical Substances

Vanadium pentoxide (dust)

RTECS #: YW2450000

CAS #: 1314-62-1

UPDATE: May 2004 MW: 181.88 MF: O5V2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Anhydride vanadique (French)
  2. C.I. 77938
  3. Divanandium pentoxide
  4. RCRA waste number P120
  5. Vanadic anhydride
  6. Vanadio, pentossido di (Italian)
  7. Vanadium (OSHA)
  8. Vanadium oxide (V2O5)
  1. Vanadium pentaoxide
  2. Vanadium pentoxide
  3. Vanadium pentoxide (ACGIH)
  4. Vanadium, pentoxyde de (French)
  5. Vanadiumpentoxid (German)
  6. Vanadiumpentoxyde (Dutch)
  7. Wanadu pieciotlenek (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate NTIS** OTS0534556


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human leukocyte 300 nmol/L MUREAV 359,77,1996
DNA damage human lymphocyte 30 µmol/L MUREAV 359,77,1996
DNA repair Bacillus subtilis 500 mmol/L MUREAV 77,109,1980
micronucleus test hamster lung 1 mg/L MUREAV 321,35,1994
sex chromosome loss and nondisjunction human lymphocyte 10 nmol/L MUREAV 386,291,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 179 mg/kg (60 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		56ZJAL 4,423,1996
intraperitoneal
mouse 		lowest published toxic dose: 85 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		MSCREJ 21,711,1993
intraperitoneal
mouse 		lowest published toxic dose: 85 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus MSCREJ 21,711,1993
intraperitoneal
mouse 		lowest published toxic dose: 170 mg/kg (60 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TCMUD8 16,7,1996
intraperitoneal
mouse 		lowest published toxic dose: 170 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		TCMUD8 16,7,1996
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		CHYCDW 20,189,1986
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		HYDXET 24,92,1993
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		HYDXET 24,202,1993
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		HYDXET 24,202,1993
intravenous
mouse 		lowest published toxic dose: 10,900 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ENVRAL 33,47,1984
oral
rat 		lowest published toxic dose: 90 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		CHYCDW 20,189,1986
oral
rat 		lowest published toxic dose: 180 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus CHYCDW 20,189,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 500 mg/m3/23 minute N/R 30ZIAO -,72,1964
inhalation
human 		lowest published toxic concentration: 346 mg/m3 Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Sputum 		AMIHAB 19,497,1959
inhalation
human 		lowest published toxic concentration: 1 mg/m3/8 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Eye: Conjunctiva irritation 		AEHLAU 14,709,1967
inhalation
rat 		lethal concentration (50 percent kill): 126 mg/m3/6 hour Eye: Other eye effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0534556-1
intraperitoneal
mouse 		lethal dose (50 percent kill): 23 mg/kg N/R TCMUD8 16,7,1996
intraperitoneal
rat 		lethal dose (50 percent kill): 12 mg/kg N/R ATXKA8 16,182,1956
intratracheal
rat 		lethal dose (50 percent kill): 6 mg/kg N/R BCTKAG 11,191,1978
oral
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R GISAAA 26(10),6,1961
oral
rat 		lethal dose (50 percent kill): 10 mg/kg Behavioral: Coma ATXKA8 16,182,1956
subcutaneous
guinea pig 		lowest published lethal dose: 20 mg/kg N/R 30ZIAO -,69,1964
subcutaneous
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R ZVKOA6 19,186,1974
subcutaneous
rat 		lethal dose (50 percent kill): 14 mg/kg Behavioral: Coma ATXKA8 16,182,1956
skin
rabbit 		lethal dose (50 percent kill): 50 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0534556


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/24 hour/24 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 48(9),77,1983
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/1 hour/13 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 22(3),25,1957
inhalation
rat 		lowest published toxic concentration: 60 µg/m3/4 hour/22 week- intermittent Liver: Fatty liver degeneration

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		WDZAEK 4,32,1990
intraperitoneal
rat 		lowest published toxic dose: 56 mg/kg/14 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 11,119,1982
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg/4 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition 		WDZAEK 4,105,1990
intratracheal
rat 		lowest published toxic dose: 7,200 µg/kg/1 year- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		BCTKAG 11,191,1978
oral
rat 		lowest published toxic dose: 91 mg/kg/26 week- intermittent Behavioral: Alteration of operant conditioning GISAAA 26(10),6,1961
oral
rat 		lowest published toxic dose: 1,280 mg/kg/15 week- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Skin and Appendages: Other: Hair 		AMIHBC 8,406,1953


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(V2O5)/m3 (R) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
FRMBAZ 21,325,1973
TOXICOLOGY REVIEW
85DHAX V,46,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 0.5 mg/m3 DTLVS* 3,275,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.5 mg(V2O5)/m3, respirable dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.5 mg(V2O5)/m3, respirable fraction CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 0.05 mg/m3, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.03 mg(V)/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg((V2O5)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (175 mg/m3), JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VANADIUM (as V2O5), resp dust/fume-air ceiling concentration 0.05 mg/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76210;
Number of Industries 7;
Total Number of Facilities 333;
Number of Occupations 12;
Total Number of Employees Exposed 2,562
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76210;
Number of Industries 6;
Total Number of Facilities 67;
Number of Occupations 17;
Total Number of Employees Exposed 4,468;
Total Number of Female Employees Exposed 541


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vanadium oxides, 7504
NIOSH Analytical Method, 1996: Elements by ICP, 7300
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
OSHA ANALYTICAL METHOD #ID-185


REFERENCES:

CODEN
REFERENCE
30ZIAO "Vanadium Toxicology and Biological Significance," Faulkner, T.G., New York, Elsevier Science Pub. Co., 1964
56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris, France, 1990.
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FRMBAZ Farmacia (Bucharest). (Rompresfilatelia, POB 12-201, Bucharest, Romania) V.1- 1953-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYDXET Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.17- 1986-
MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

NIOSH PROFILE (INCINERATION), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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