The Registry of Toxic Effects of Chemical Substances

Valeraldehyde

RTECS #: YV3600000

CAS #: 110-62-3

UPDATE: November 2004 MW: 86.15 MF: C5H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amyl aldehyde
  2. Butyl formal
  3. Pentanal
  4. Valeral
  5. Valerianic aldehyde
  6. Valeric acid aldehyde
  1. Valeric aldehyde
  2. Valerylaldehyde
  3. n - Pentanal
  4. n - Valeraldehyde
  5. n - Valeraldehyde (ACGIH)
  6. n - Valeric aldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour severe FCTXAV 17,919,1979
skin
guinea pig 		1,00% severe FCTXAV 17,919,1979
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,919,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 3 µmol/L MUREAV 323,121,1994
mutation in mammalian somatic cells hamster lung 10 mmol/L MUTAEX 4,277,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R AIHAAP 30,470,1969
inhalation
rat 		lethal concentration (50 percent kill): 14,000 mg/m3/4 hour N/R VCVGK* -,376,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Ataxia 		NTIS** OTS0533619
intraperitoneal
rat 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		NTIS** OTS0533619
oral
mouse 		lethal dose (50 percent kill): 6.4 mg/kg N/R VCVGK* -,376,1984
oral
rat 		lethal dose (50 percent kill): 5,660 µL/kg N/R AIHAAP 30,470,1969
oral
rat 		lethal dose (50 percent kill): 5.66 mg/kg N/R VCVGK* -,376,1984
subcutaneous
mouse 		lowest published lethal dose: 2 gm/kg N/R APFRAD 14,710,1956
skin
guinea pig 		lethal dose (50 percent kill): 20 gm/kg N/R FCTXAV 17,919,1979
skin
rabbit 		lethal dose (50 percent kill): 5 mL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0535072


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (175 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (176 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (175 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (175 mg/m3), short term exposure limit 75 ppm (265 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (175 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (175 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 175 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-VALERALDEHYDE-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0122;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 5;
Total Number of Employees Exposed 1,557;
Total Number of Female Employees Exposed 276


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in flavoring compounds, in resin chemistry, and as a rubber accelerator
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH Analytical Method, 1994: Valeraldehyde, 2536
OSHA ANALYTICAL METHOD #85


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in flavoring compounds, in resin chemistry, and as a rubber accelerator

RTECS Compound Description:
   Mutagen
   Primary Irritant

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