The Registry of Toxic Effects of Chemical Substances

Urea, 1 - (1 - naphthyl) - 2 - thio -

RTECS #: YT9275000

CAS #: 86-88-4

UPDATE: November 2004 MW: 202.29 MF: C11H10N2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (1 - Naphthyl) - 2 - thiourea
  2. 1 - Naftil - tiourea (Italian)
  3. 1 - Naftylthioureum (Dutch)
  4. 1 - Naphthalenylthiourea
  5. 1 - Naphthyl thiourea
  6. 1 - Naphthyl - thioharnstoff (German)
  7. 1 - Naphthyl - thiouree (French)
  8. ANTU
  9. ANTU (ACGIH:OSHA)
  10. Alphanaphthyl thiourea
  11. Alphanaphtyl thiouree (French)
  12. Alrato
  13. Anturat
  14. Bantu
  15. Chemical 109
  16. Dirax
  17. Kill kantz
  1. Krysid
  2. Krysid PI
  3. N - (1 - Naphthyl) - 2 - thiourea
  4. Naphtox
  5. RCRA waste number P072
  6. Rat - TU
  7. Rattrack
  8. Smeesana
  9. Thiourea, 1 - naphthalenyl -
  10. U - 5227
  11. USAF EK - P - 5976
  12. alpha - Naftylthiomocovina (Czech)
  13. alpha - Naphthalthioharnstoff (German)
  14. alpha - Naphthothiourea
  15. alpha - Naphthylthiocarbamide
  16. alpha - Naphthylthiourea
  17. alpha - Naphthylthiourea (DOT:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 nmol/L (-enzymatic activation step) ENMUDM 3,11,1981
morphological transform hamster embryo 1,600 µg/L NCIMAV 58,243,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
chicken 		lethal dose (50 percent kill): 2,500 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
dog 		lethal dose (50 percent kill): 16 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 350 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
monkey 		lethal dose (50 percent kill): 175 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 2,470 µg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion 		JPETAB 97,432,1949
oral
cat 		lethal dose (50 percent kill): 500 mg/kg N/R PSEBAA 62,22,1946
oral
chicken 		lethal dose (50 percent kill): 4,250 mg/kg N/R PSEBAA 62,22,1946
oral
dog 		lethal dose (50 percent kill): 380 µg/kg N/R PCOC** -,57,1966
oral
monkey 		lethal dose (50 percent kill): 4,250 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R YKYUA6 28,329,1977
oral
pig 		lowest published lethal dose: 50 mg/kg N/R YKYUA6 28,329,1977
oral
rat 		lethal dose (50 percent kill): 6 mg/kg N/R AFDOAQ 16,47,1952
unreported route
chicken 		lethal dose (50 percent kill): 700 mg/kg N/R 30ZDA9 -,238,1971
unreported route
man 		lowest published lethal dose: 588 mg/kg N/R 85DCAI 2,73,1970
unreported route
monkey 		lethal dose (50 percent kill): >2 gm/kg N/R BCFAAI 97,289,1958
unreported route
rabbit 		lethal dose (50 percent kill): >200 mg/kg N/R BCFAAI 97,289,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.3 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,263,1987
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.3 mg/m3 DTLVS* 3,14,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.3 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.3 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.3 mg/m3, short term exposure limit 0.9 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.3 mg/m3, continuous3 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.3 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.3 mg/m3, KZG- week 1.5 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTU-air 10 hour time-weighted average 0.3 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0294;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 4;
Total Number of Employees Exposed 1,450


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as rodenticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as rodenticide

NIOSH PROFILE (THIOUREA AND COMPOUNDS), SRC, 1/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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