The Registry of Toxic Effects of Chemical Substances

Urea, 3 - (3,4 - dichlorophenyl) - 1 - methoxy - 1 - methyl -

RTECS #: YS9100000

CAS #: 330-55-2

UPDATE: November 2004 MW: 249.11 MF: C9H10Cl2N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Afalon
  2. Afalon inuron
  3. Aphalon
  4. Cephalon
  5. 3 - (3,4 - Dichloor - fenyl) - 1 - methoxy - 1 - methylureum (Dutch)
  6. 3 - (3,4 - Dichloro - fenil) - 1 - metossi - 1 - metil - urea (Italian)
  7. 3 - (3,4 - Dichlorophenyl) - 1 - methoxymethylurea
  8. 3 - (3,4 - Dichlorophenyl) - 1 - methoxy - 1 - methylurea
  9. N' - (3,4 - Dichlorophenyl) - N - methoxy - N - methylurea
  10. 1 - (3,4 - Dichlorophenyl) 3 - methoxy - 3 - methyluree (French)
  11. N - (3,4 - Dichlorophenyl) - N' - methyl - N' - methoxyurea
  12. 3 - (3,4 - Dichlor - phenyl) - 1 - methoxy - 1 - methyl - harnstoff (German)
  13. 3 - (4,5 - Dichlorphenyl) - 1 - methoxy - 1 - methylharnstoff (German)
  14. Du Pont 326
  15. Dupont herbicide 326
  16. N - (3,4 - Dwuchlorofenylo) N' - metoksy - N' - metylomocznik (Polish)
  17. Garnitan
  1. Herbicide 326
  2. HOE 2810
  3. Laroks (Polish)
  4. Linex 4L
  5. Linorox
  6. Linurex
  7. Linuron
  8. Linuron (herbicide)
  9. Lorex
  10. Lorox
  11. Lorox linuron weed killer
  12. Methoxydiuron
  13. 1 - Methoxy - 1 - methyl - 3 - (3,4 - dichlorophenyl) urea
  14. Sarclex
  15. Scarclex
  16. Sinuron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
rat 		4,500 mg/kg/2 week- intermittent MUREAV 390,207,1997
DNA inhibition oral
mouse 		500 mg/kg MUREAV 58,353,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 21.6876 mg/kg (62 day male) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 119,195,1993
oral
rat 		lowest published toxic dose: 132.06 mg/kg (62 day male) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 119,195,1993
oral
rat 		lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on newborn: Physical TXAPA9 167,87,2000
oral
rat 		lowest published toxic dose: 2,000 mg/kg (12 day prior to copulation-7 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 16,131,2002
oral
rat 		lowest published toxic dose: 300 mg/kg (12-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 16,131,2002
oral
rat 		lowest published toxic dose: 400 mg/kg (12-19 day pregnant) Reproductive: Effects on newborn: Physical REPTED 16,131,2002
oral
rat 		lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		REPTED 16,131,2002
oral
rat 		lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects

Reproductive: Effects on newborn: Germ cell effects (in offspring) 		TOSCF2 65,62,2002
oral
rat 		lowest published toxic dose: 500 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (12-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system 		TOXID9 72(Suppl 1),275,2003
oral
rat 		lowest published toxic dose: 450 mg/kg (12-21 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TOSCF2 74,114,2003
oral
rat 		lowest published toxic dose: 450 mg/kg (12-21 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		TOSCF2 65,62,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 48 mg/m3/4 hour N/R 85GMAT -,48,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 577 mg/kg N/R RREVAH 77,126,1981
oral
chicken 		lethal dose (50 percent kill): 3,765 mg/kg N/R VETNAL 58(7),63,1982
oral
dog 		lethal dose (50 percent kill): 500 mg/kg N/R GUCHAZ 6,317,1973
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R YKYUA6 36,387,1985
oral
rat 		lethal dose (50 percent kill): 1,146 mg/kg N/R FAATDF 7,299,1986
oral
rabbit 		lethal dose (50 percent kill): 2,250 mg/kg N/R 85JFAN A248,1984
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,520,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 7,500 mg/kg/30 day- intermittent Behavioral: Muscle weakness

Cardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VETNAL 58(7),63,1982
oral
chicken 		lowest published toxic dose: 1 gm/kg/10 day- intermittent Behavioral: Food intake (animal)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RREVAH 77,135,1981
oral
dog 		lowest published toxic dose: 11,400 mg/kg/2 year- continuous Liver: Other changes

Blood: Other hemolysis with or without anemia

Blood: Changes in erythrocyte (RBC) count 		FCTXAV 6,171,1968
oral
dog 		lowest published toxic dose: 1,050 mg/kg/7 day- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		RREVAH 77,130,1981
oral
domestic animal 		lowest published toxic dose: 1,750 mg/kg/7 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VETNAL 58(7),63,1982
oral
domestic animal 		lowest published toxic dose: 600 mg/kg/6 day- intermittent Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RREVAH 77,135,1981
oral
domestic animal 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RREVAH 77,135,1981
oral
rat 		lowest published toxic dose: 10 gm/kg/60 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		RPZHAW 21,145,1970
oral
rat 		lowest published toxic dose: 1,070 mg/kg/31 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		GISAAA 40(7),46,1975
oral
rat 		lowest published toxic dose: 1,500 mg/kg/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		JEPOEC 13,11,1994
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight 		TXAPA9 119,195,1993
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- continuous Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight 		TXAPA9 119,195,1993
oral
rat 		lowest published toxic dose: 497 mg/kg/14 day- continuous Endocrine: Change in LH

Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 119,195,1993
oral
rat 		lowest published toxic dose: 22,750 mg/kg/2 year- continuous Blood: Other hemolysis with or without anemia

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTXAV 6,171,1968
oral
rat 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 65,62,2002
oral
rat 		lowest published toxic dose: 1,820 mg/kg/104 week- continuous Reproductive: Tumorigenic effects: Testicular tumors HBPTO* 1,814,2001
oral
rat 		lowest published toxic dose: 375 mg/kg/15 day- intermittent Liver: Changes in liver weight TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 2,250 mg/kg/15 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 450 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 74,114,2003
oral
rabbit 		lowest published toxic dose: 10 gm/kg/10 day- intermittent Cardiac: EKG changes not diagnostic of above

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VETNAL 58(7),63,1982
unreported route
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- continuous Endocrine: Change in LH

Endocrine: Estrogenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		HBPTO* 1,734,2001
unreported route
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands HBPTO* 1,734,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,125,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for selective weed control in field corn, grain sorghum, soybeans, carrots, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used for selective weed control in field corn, grain sorghum, soybeans, carrots, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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