The Registry of Toxic Effects of Chemical Substances

Urea, 3 - (3,4 - dichlorophenyl) - 1,1 - dimethyl -

RTECS #: YS8925000

CAS #: 330-54-1

UPDATE: November 2004 MW: 233.11 MF: C9H10Cl2N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AF 101
  2. 1,1 - Dimethyl - 3 - (3,4 - dichlorophenyl) urea
  3. Unidron
  4. DCMU
  5. Dichlorfenidim
  6. 3 - (3,4 - Dichlorophenol) - 1,1 - dimethylurea
  7. N' - (3,4 - Dichlorophenyl) - N,N - dimethylurea
  8. 3 - (3,4 - Dichlorophenyl) - 1,1 - dimethylurea
  9. 1 - (3,4 - Dichlorophenyl) - 3,3 - dimethyluree (French)
  10. 3 - (3,4 - Dichlor - phenyl) - 1,1 - dimethyl - harnstoff (German)
  11. 3 - (3,4 - Dichloor - fenyl) - 1,1 - dimethylureum (Dutch)
  12. 3 - (3,4 - Dicloro - fenyl) - 1,1 - dimetil - urea (Italian)
  13. Direx 4L
  14. Diuron
  15. Diuron (ACGIH)
  16. Diuron 4L
  1. DMU
  2. DP Hardener 95
  3. Duran
  4. Farmco diuron
  5. Herbatox
  6. HW 920
  7. Karmex
  8. Karmex Diuron Herbicide
  9. Karmex DW
  10. Lucenit
  11. Marmer
  12. Sup'r flo
  13. Telvar diuron weed killer
  14. USAF XR - 42
  15. USAF P - 7


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition oral
mouse 		1 gm/kg MUREAV 58,353,1978
mutation in microorganisms Salmonella typhimurium 3 µg/plate (-enzymatic activation step) MUREAV 58,353,1978
micronucleus test intraperitoneal
mouse 		170 mg/kg HBPTO* 2,1523,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 360 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) GISAAA 49(8),83,1984
oral
rat 		lowest published toxic dose: 1,250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BECTA6 22,522,1979
subcutaneous
mouse 		lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear 		NTIS** PB223-160
unreported route
mammal (species unspecified) 		lowest published toxic dose: 144 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 64,41302,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 153 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
oral
rat 		lethal dose (50 percent kill): 1,017 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia 		JAFCAU 18,1104,1970
oral
rat 		lethal dose (50 percent kill): 1 gm/kg N/R HBPTO* 2,1522,2001
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FMCHA2 -,C115,1991
unreported route
duck 		lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C115,1991
unreported route
rat 		lethal dose (50 percent kill): 3,400 mg/kg N/R 30ZDA9 -,231,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 90 mg/m3/4 hour/60 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in spleen

Endocrine: Changes in thyroid weight 		GISAAA 34(6),27,1969
oral
rat 		lowest published toxic dose: 61,250 mg/kg/35 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		IJEBA6 37,503,1999
oral
rat 		lowest published toxic dose: 52,500 µg/kg/30 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TXAPA9 36,76,1990
oral
rat 		lowest published toxic dose: 13,620 mg/kg/61 week- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		FCTOD7 31,285,1993
oral
rat 		lowest published toxic dose: 10 gm/kg/10 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1522,2001
oral
rat 		lowest published toxic dose: 9 gm/kg/30 day- continuous Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1522,2001
oral
rat 		lowest published toxic dose: 18 gm/kg/30 day- continuous Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1522,2001
oral
rat 		lowest published toxic dose: 3,375 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1522,2001
oral
rat 		lowest published toxic dose: 16.88 gm/kg/90 day- continuous Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above 		HBPTO* 2,1522,2001
oral
rat 		lowest published toxic dose: 7,987.5 mg/kg/426 day- continuous Endocrine: Changes in spleen weight

Blood: Normocytic anemia

Blood: Changes in cell count (unspecified) 		HBPTO* 2,1523,2001
oral
rat 		lowest published toxic dose: 5,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1523,2001
oral
rat 		lowest published toxic dose: 682.5 mg/kg/13 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) HBPTO* 2,1523,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,115,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIURON-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0785;
Number of Industries 2;
Total Number of Facilities 120;
Number of Occupations 2;
Total Number of Employees Exposed 374
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0785;
Number of Industries 8;
Total Number of Facilities 75;
Number of Occupations 12;
Total Number of Employees Exposed 4,216;
Total Number of Female Employees Exposed 264


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as selective herbicide for control of germinating broadleaf and grass weeds in crops
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as selective herbicide for control of germinating broadleaf and grass weeds in crops

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 102962-29-8
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