The Registry of Toxic Effects of Chemical Substances

Tributylamine

RTECS #: YA0350000

CAS #: 102-82-9

UPDATE: October 1997 MW: 185.40 MF: C12H27N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Butanamine, N,N - dibutyl -
  2. Tributilamina (Romanian)
  1. Tri - n - butylamine
  2. Tris - n - butylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 75 ppm/4 hour N/R TXAPA9 28,313,1974
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 107 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement 		GTPZAB 28(11),50,1984
oral
guinea pig 		lethal dose (50 percent kill): 350 mg/kg N/R GISAAA 42(12),36,1977
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 888 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement 		GTPZAB 28(11),50,1984
oral
mouse 		lethal dose (50 percent kill): 114 mg/kg N/R GISAAA 42(12),36,1977
oral
rat 		lethal dose (50 percent kill): 114 mg/kg N/R TLSMA6 115,57,1977
oral
rabbit 		lethal dose (50 percent kill): 615 mg/kg N/R GISAAA 42(12),36,1977
subcutaneous
rat 		lowest published lethal dose: 380 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 20,435,1923
skin
rabbit 		lethal dose (50 percent kill): 250 µL/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 107 mg/kg/3 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase 		GTPZAB 28(11),50,1984
oral
rabbit 		lowest published toxic dose: 1,119 mg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 42(12),36,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83937;
Number of Industries 48;
Total Number of Facilities 2,039;
Number of Occupations 33;
Total Number of Employees Exposed 27,671
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83937;
Number of Industries 36;
Total Number of Facilities 2,898;
Number of Occupations 31;
Total Number of Employees Exposed 51,214;
Total Number of Female Employees Exposed 15,366


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

NIOSH PROFILE (AMINES, TERTIARY ALIPHATIC), SRI, 2/77

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