The Registry of Toxic Effects of Chemical Substances

as - Triazin - 5 (4H) - one, 4 - amino - 6 - tert - butyl - 3 - (methylthio) -

RTECS #: XZ2990000

CAS #: 21087-64-9

UPDATE: November 2004 MW: 214.32 MF: C8H14N4OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2,4 - Triazin - 5 (4H) - one, 4 - amino - 6 - (1,1 - dimethylethyl) - 3 - (methylthio) -
  2. 1,2,4 - Triazin - 5 - one, 4 - amino - 6 - tert - butyl - 3 - (methylthio) -
  3. 4 - Amino - 6 - (1,1 - dimethylethyl) - 3 - (methylthio) - 1,2,4 - triazin - 5 (4H) - one
  4. 4 - Amino - 6 - tert - butyl - 3 - (methylthio) - 1,2,4 - triazin - 5 - one
  5. 4 - Amino - 6 - tert - butyl - 3 - methylthio - as - triazin - 5 - one
  6. BAY 61597
  7. BAY dic 1468
  8. Bayer 6159H
  9. Bayer 6443H
  10. Bayer 94337
  11. DIC 1468
  12. Lexone
  1. Lexone 4L
  2. Lexone DF
  3. Metribuzin
  4. Metribuzin (ACGIH)
  5. NTN 70
  6. Sencor
  7. Sencor 4
  8. Sencor DF
  9. Sencoral
  10. Sencorer
  11. Sencorex
  12. Zenkor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NNGADV 12,127,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >860 mg/m3/4 hour N/R 85INA8 6,1042,1991
inhalation
rat 		lethal concentration (50 percent kill): >860 mg/m3/4 hour N/R NNGADV 12,127,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 210 mg/kg Behavioral: Somnolence (general depressed activity) PCBPBS 23,123,1984
intraperitoneal
rat 		lethal dose (50 percent kill): 239 mg/kg N/R NNGADV 12,127,1987
oral
cat 		lethal dose (50 percent kill): >500 mg/kg N/R 85JFAN A280,1983
oral
guinea pig 		lethal dose (50 percent kill): 250 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse 		lethal dose (50 percent kill): 564 mg/kg N/R NNGADV 12,127,1987
oral
quail 		lethal dose (50 percent kill): 164 mg/kg N/R PEMNDP 8,573,1987
oral
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R FMCHA2 -,C204,1991
subcutaneous
mouse 		lethal dose (50 percent kill): 367 mg/kg N/R NNGADV 12,127,1987
subcutaneous
rat 		lethal dose (50 percent kill): 814 mg/kg N/R NNGADV 12,127,1987
skin
mouse 		lethal dose (50 percent kill): >1 gm/kg N/R NNGADV 12,127,1987
skin
rat 		lethal dose (50 percent kill): 2 gm/kg N/R 85JCAE -,1001,1986
skin
rabbit 		lethal dose (50 percent kill): >20 gm/kg N/R FMCHA2 -,C204,1991
unreported route
quail 		lethal dose (50 percent kill): 168 mg/kg N/R FMCHA2 -,C204,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 27,375 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NNGADV 12,127,1987
oral
dog 		lowest published toxic dose: 27.3 gm/kg/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 65.7 gm/kg/78 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Other changes 		HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 64,800 µg/kg/15 week- continuous Brain and Coverings: Other degenerative changes JTEHD6 30,209,1990
oral
rat 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Immunological Including Allergic: Increased immune response GISAAA 52(11),76,1987
oral
rat 		lowest published toxic dose: 13,140 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NNGADV 12,127,1987
oral
rat 		lowest published toxic dose: 10.92 gm/kg/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 10.95 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 10.95 gm/kg/2 year- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) 		HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,133,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METRIBUZIN-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
Used for control of a large number of grass and broadleaf weeds infesting agricultural crops
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used for control of a large number of grass and broadleaf weeds infesting agricultural crops

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

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