The Registry of Toxic Effects of Chemical Substances

s - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (2,3 - epoxypropyl) -

RTECS #: XZ1994900

CAS #: 2451-62-9

UPDATE: November 2004 MW: 297.30 MF: C12H15N3O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (oxiranemethyl) - (9CI)
  2. 1,3,5 - Triglycidyl isocyanurate
  3. 1,3,5 - Triglycidyl - s - triazinetrione
  4. 1,3,5 - Triglycidylisocyanuric acid
  5. 1,3,5 - Tris (oxiranylmethyl) - 1,3,5 - triazine - 2,4,6 (1H,3H,5H) - trione
  6. Araldite PT 810
  7. Glycidyl isocyanurate
  1. N,N',N'' - Triglycidyl isocyanurate
  2. TGT
  3. Triglycidyl isocyanurate
  4. Tris (2,3 - epoxypropyl) isocyanurate
  5. Tris (epoxypropyl) isocyanurate
  6. s - Triazine - 2,4,6 (1H,3H,5H) - trione, 1,3,5 - tris (2,3 - epoxypropyl) - (8CI)
  7. s - Triazine - 2,4,6 (1H,3H,5H) - trione, tris (2,3 - epoxypropyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1,200 µg/L MUREAV 241,175,1990
cytogenetic analysis oral
mouse 		4 gm/kg/5 day- continuous EPASR* 8EHQ-0491-0490
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+enzymatic activation step) EMMUEG 19(Suppl 21),2,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** OTS0555023


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 188 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair 		NTIS** OTS0555027


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8890
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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