The Registry of Toxic Effects of Chemical Substances

s - Triazine, 2,4,6 - trichloro -

RTECS #: XZ1400000

CAS #: 108-77-0

UPDATE: March 2000 MW: 184.41 MF: C3Cl3N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Chlorotriazine
  2. Cyanurchloride
  3. Cyanuric acid chloride
  4. Cyanuric trichloride
  5. Cyanuryl chloride
  6. Kyanurchlorid (Czech)
  7. s - Triazine trichloride
  8. Trichlorocyanidine
  1. Trichloro - s - triazine
  2. sym - Trichlorotriazine
  3. 1,3,5 - Trichlorotriazine
  4. 2,4,6 - Trichlorotriazine
  5. 2,4,6 - Trichloro - s - triazine
  6. 2,4,6 - Trichloro - 1,3,5 - triazine
  7. syn - Trichlotriazin (Czech)
  8. Tricyanogen chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 28ZPAK -,152,1972
skin
rabbit 		500 mg/24 hour moderate 28ZPAK -,152,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
multiple
rat 		lowest published toxic dose: 16 gm/kg/73 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 12(4),78,1966
oral
rat 		lowest published toxic dose: 20 gm/kg/73 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		VOONAW 12(4),78,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 10 mg/m3/2 hour Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Musculoskeletal: Other changes 		GTPZAB 12(8),35,1968
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R 38MKAJ 2C,4891,1982
intravenous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#07336
oral
mouse 		lethal dose (50 percent kill): 350 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 12(8),35,1968
oral
rat 		lethal dose (50 percent kill): 485 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease 		GTPZAB 12(8),35,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,880 µg/m3/4 hour/11 week- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 12(8),35,1968
oral
rat 		lowest published toxic dose: 2,800 mg/kg/28 day- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 12,119,1992
oral
rat 		lowest published toxic dose: 100 mg/kg/5 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0545266


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4559;
Number of Industries 2;
Total Number of Facilities 20;
Number of Occupations 3;
Total Number of Employees Exposed 2,336;
Total Number of Female Employees Exposed 299


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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