The Registry of Toxic Effects of Chemical Substances

s - Triazine, 2 - chloro - 4 - ethylamino - 6 - isopropylamino -

RTECS #: XY5600000

CAS #: 1912-24-9

UPDATE: May 2005 MW: 215.72 MF: C8H14ClN5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4 - diamine, 6 - chloro - N - ethyl - N' - (1 - methylethyl) - (9CI)
  2. 1 - Chloro - 3 - ethylamino - 5 - isopropylamino - 2,4,6 - triazine
  3. 1 - Chloro - 3 - ethylamino - 5 - isopropylamino - s - triazine
  4. 2 - Aethylamino - 4 - chlor - 6 - isopropylamino - 1,3,5 - triazin (German)
  5. 2 - Aethylamino - 4 - isopropylamino - 6 - chlor - 1,3,5 - triazin (German)
  6. 2 - Chloro - 4 - (2 - propylamino) - 6 - ethylamino - s - triazine
  7. 2 - Chloro - 4 - ethylamineisopropylamine - s - triazine
  8. 2 - Chloro - 4 - ethylamino - 6 - isopropylamino - 1,3,5 - triazine
  9. 2 - Chloro - 4 - ethylamino - 6 - isopropylamino - s - triazine
  10. 6 - Chloro - N - ethyl - N' - (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  11. 6 - Chloro - N - ethyl - N9 - (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  12. A 361
  13. Aatram 20G
  14. Aatrex
  15. Aatrex 4L
  16. Aatrex 80W
  17. Aatrex nine - O
  18. Aktikon
  19. Aktikon PK
  20. Aktinit A
  21. Aktinit PK
  22. Aneldazin
  23. Argezin
  24. Atrataf
  25. Atrazin
  26. Atrazine
  1. Atrazine (ACGIH)
  2. Azoprim
  3. Ceasin 50
  4. Cekuzina - T
  5. Chromozin
  6. Cyazin
  7. G 30027
  8. Geigy 30,027
  9. Gesaprim
  10. Herbatoxol
  11. Hungazin
  12. Hungazin PK
  13. Oleogesaprim
  14. Primatol A
  15. Radazin
  16. Technical atrazine
  17. Technical grade atrazine
  18. Triazine A 1294
  19. Vectal
  20. Vectal SC
  21. Weedex A
  22. Wonuk
  23. Zeapos
  24. Zeazin
  25. Zeazine
  26. Zeopos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
mammal (species unspecified) 		100 mg severe VRDEA5 (5),133,1977
eye
rabbit 		6,320 µg severe CIGET* -,-,1977
skin
mammal (species unspecified) 		500 mg mild VRDEA5 (5),133,1977
skin
rabbit 		38 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 1 mg/L MUREAV 281,295,1992
cytogenetic analysis oral
mouse 		72 mg/kg/30 day- continuous EMMUEG 19,77,1992
dominant lethal test parenteral
Drosophila melanogaster 		556 µmol/L JTEHD6 3,691,1977
dominant lethal test oral
Drosophila melanogaster 		100 ppm JTEHD6 3,691,1977
dominant lethal test oral
mouse 		1,500 mg/kg MUREAV 74,77,1980
DNA damage human lymphocyte 100 mg/L MUREAV 344,41,1995
DNA damage intraperitoneal
mouse 		500 mg/kg MUREAV 493,1,2001
DNA damage oral
rat 		875 mg/kg MUREAV 209,145,1988
unscheduled DNA synthesis human fibroblast 3 mmol/L MUREAV 74,77,1980
host-mediated assay mouse
Escherichia coli 		100 mg/kg MUREAV 74,77,1980
host-mediated assay rat
Escherichia coli 		100 mg/kg CECED9 6388,328,1980
mutation in microorganisms Aspergillus nidulans 6 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
mutation in microorganisms hamster lung 3 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
mutation in microorganisms Schizosaccharomyces pombe 6 mmol/L (+enzymatic activation step) MUREAV 74,77,1980
gene conversion and mitotic recombination Aspergillus nidulans 6 mmol/L MUREAV 74,77,1980
other mutation test systems oral
mouse 		216 mg/kg/90 day- continuous EMMUEG 19,77,1992
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		100 ppm JTEHD6 3,691,1977
sex chromosome loss and nondisjunction Neurospora crassa 10 mg/L MUREAV 167,35,1986
specific locus test oral
Drosophila melanogaster 		5 mmol/L MUREAV 280,291,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,028 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JJATDK 20,61,2000
oral
rat 		lowest published toxic dose: 7 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 24,307,1988
oral
rat 		lowest published toxic dose: 700 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTEHD6 24,307,1988
oral
rat 		lowest published toxic dose: 720 mg/kg (10 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral 		APHHDU 83,79,1995
oral
rat 		lowest published toxic dose: 125 mg/kg (5 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 52,68,1999
oral
rat 		lowest published toxic dose: 1,000 mg/kg (6-10 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 1,000 mg/kg (11-15 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 500 mg/kg (6-10 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 600 mg/kg (8-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 1,000 mg/kg (6-10 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 35 mg/kg (10 day pregnant-23 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOXID9 72,120,2003
oral
rat 		lowest published toxic dose: 200 mg/kg (6-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOXID9 72,77,2003
oral
rat 		lowest published toxic dose: 500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOXID9 72,77,2003
oral
rat 		lowest published toxic dose: 1,260 mg/kg (10-22 day pregnant/23 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		TOSCF2 76,366,2003
oral
rabbit 		lowest published toxic dose: 975 mg/kg (7-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JTEHD6 24,307,1988
oral
rabbit 		lowest published toxic dose: 975 mg/kg (7-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 24,307,1988
subcutaneous
mouse 		lowest published toxic dose: 418 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB223-160
subcutaneous
rat 		lowest published toxic dose: 2,400 mg/kg (3-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) BECTA6 9,301,1973
subcutaneous
rat 		lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BECTA6 9,301,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 9,000 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159
oral
rat 		lowest published toxic dose: 33,775 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Uterine tumors 		NEOLA4 37,533,1990
oral
rat 		lowest published toxic dose: 36.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors 		HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 5,200 mg/m3/4 hour N/R FMCHA2 -,C29,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 626 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Endocrine: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response 		TOXID9 72,172,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 235 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg Liver: Other changes ETOPFR 12,1,2002
oral
hamster 		lethal dose (50 percent kill): 1 gm/kg N/R TXAPA9 48,A192,1979
oral
mouse 		lethal dose (50 percent kill): 850 mg/kg N/R 85GMAT -,36,1982
oral
mouse 		lowest published toxic dose: 875 mg/kg Endocrine: Changes in thymus weight

Blood: Changes in spleen 		TOXID9 72(Suppl 1),329,2003
oral
mouse 		lowest published toxic dose: 8.75 mg/kg Immunological Including Allergic: Decrease in cellular immune response TOXID9 72(Suppl 1),329,2003
oral
rat 		lethal dose (50 percent kill): 672 mg/kg N/R FAATDF 7,299,1986
oral
rat 		lowest published toxic dose: 300 mg/kg Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TOSCF2 53,297,2000
oral
rat 		lowest published toxic dose: 40 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,77,2003
oral
rabbit 		lethal dose (50 percent kill): 750 mg/kg N/R 85DPAN -,-,1971/1976
skin
rat 		lethal dose (50 percent kill): >12,500 mg/kg N/R GISAAA 55(7),87,1990
skin
rabbit 		lethal dose (50 percent kill): 7,500 mg/kg N/R 28ZEAL 5,15,1976
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,400 mg/kg N/R GISAAA 44(6),81,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/26 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		KHZDAN 12,114,1969
intraperitoneal
rat 		lowest published toxic dose: 360 mg/kg/23 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 20,61,2000
intraperitoneal
rat 		lowest published toxic dose: 1,020 mg/kg/60 day- intermittent Endocrine: Changes in pituitary weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight 		JAPTO* 20,61,2000
intraperitoneal
rat 		lowest published toxic dose: 2,040 mg/kg/60 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JAPTO* 20,61,2000
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		ETOPFR 12,1,2002
oral
dog 		lowest published toxic dose: 9,125 mg/kg/1 year- continuous Cardiac: Changes in coronary arteries

Cardiac: Pulse rate increased without fall in BP

Cardiac: Other changes 		NTIS** OTS0543210
oral
dog 		lowest published toxic dose: 9,100 mg/kg/52 week- intermittent Cardiac: Other changes HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Liver: Changes in liver weight AECTCV 24,449,1993
oral
mouse 		lowest published toxic dose: 20.8 gm/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
pig 		lowest published toxic dose: 38 mg/kg/19 day- intermittent Endocrine: Change in LH

Endocrine: Effect on menstrual cycle 		TOLED5 85,9,1996
oral
rat 		lowest published toxic dose: 6 gm/kg/30 day- intermittent Endocrine: Other changes

Related to Chronic Data: Changes in prostate weight 		TOXID9 54,366,2000
oral
rat 		lowest published toxic dose: 33,572 mg/kg/22 week- intermittent Liver: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		KHZDAN 12,114,1969
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes 		BECTA6 36,325,1986
oral
rat 		lowest published toxic dose: 4,200 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		JJATDK 7,373,1987
oral
rat 		lowest published toxic dose: 3,825 mg/kg/21 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders REPTED 10,257,1996
oral
rat 		lowest published toxic dose: 250 mg/kg/5 day- intermittent Endocrine: Other changes TOSCF2 52,68,1999
oral
rat 		lowest published toxic dose: 125 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 600 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 15,61,2000
oral
rat 		lowest published toxic dose: 900 mg/kg/3 day- intermittent Endocrine: Other changes TOSCF2 53,297,2000
oral
rat 		lowest published toxic dose: 3,150 mg/kg/21 day- intermittent Endocrine: Change in LH

Endocrine: Other changes 		TOSCF2 53,297,2000
oral
rat 		lowest published toxic dose: 1,575 mg/kg/21 day- intermittent Endocrine: Change in LH TOSCF2 53,297,2000
oral
rat 		lowest published toxic dose: 900 mg/kg/3 day- intermittent Reproductive: Maternal effects: Oogenesis TOSCF2 53,297,2000
oral
rat 		lowest published toxic dose: 400 mg/kg/8 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 58,135,2000
oral
rat 		lowest published toxic dose: 800 mg/kg/8 day- intermittent Endocrine: Change in LH

Endocrine: Other changes

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		TOSCF2 58,135,2000
oral
rat 		lowest published toxic dose: 800 mg/kg/8 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 58,135,2000
oral
rat 		lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Endocrine: Estrogenic TOSCF2 58,135,2000
oral
rat 		lowest published toxic dose: 145,600 mg/kg/104 week- continuous Endocrine: Tumors

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) 		HBPTO* 1,738,2001
oral
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Endocrine: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		HBPTO* 1,738,2001
oral
rat 		lowest published toxic dose: 98 mg/kg/4 week- continuous Endocrine: Effect on menstrual cycle JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 7,280 mg/kg/52 week- continuous Skin and Appendages: Other: Breast JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight 		JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Endocrine: Estrogenic

Endocrine: Effect on menstrual cycle

Blood: Other changes 		JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Endocrine: Other changes

Blood: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina 		JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 600 mg/kg/2 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Tumorigenic: Cells (cultured) transformed 		JTEHF8 43,183,1994
oral
rat 		lowest published toxic dose: 2,970 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 14.6 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Endocrine: Androgenic REPTED 16,275,2002
oral
rat 		lowest published toxic dose: 1,350 mg/kg/27 day- intermittent Endocrine: Androgenic REPTED 16,275,2002
oral
rat 		lowest published toxic dose: 420 mg/kg/7 day- intermittent Endocrine: Androgenic JSTBBK 33,141,1989
oral
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Blood: Changes in leukocyte (WBC) count HBPTO* 1,777,2001
oral
rat 		lowest published toxic dose: 1,440 mg/kg/6 day- intermittent Endocrine: Evidence of thyroid hypofunction BESCE5 9,60,1996
oral
rat 		lowest published toxic dose: 318.5 mg/kg/13 week- continuous Endocrine: Estrogenic JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 5,460 mg/kg/39 week- continuous Endocrine: Other changes JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 910 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 14,700 mg/kg/105 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 105 mg/kg/30 day- continuous Endocrine: Effect on menstrual cycle JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 315 mg/kg/90 day- continuous Endocrine: Estrogenic JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 800 mg/kg/40 week- continuous Endocrine: Change in gonadotropins JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 14,700 mg/kg/105 week- continuous Endocrine: Tumors JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 7,280 mg/kg/52 week- continuous Endocrine: Tumors JTEHD6 43,169,1994
oral
rat 		lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Endocrine: Change in LH TOXID9 72,133,2003
oral
rat 		lowest published toxic dose: 1,572.2 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,1811,2003
oral
rat 		lowest published toxic dose: 18.87 gm/kg/24 week- continuous Behavioral: Food intake (animal)

Brain and Coverings: Changes in brain weight

Related to Chronic Data: Changes in testicular weight 		FCTOD7 41,1811,2003
subcutaneous
rat 		lowest published toxic dose: 45 mg/kg/3 week- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other 		LIFSAK 69,901,2001
skin
rabbit 		lowest published toxic dose: 25 gm/kg/25 day- continuous Blood: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0555001
unreported route
rat 		lowest published toxic dose: 840 mg/kg/7 day- continuous Endocrine: Effect on menstrual cycle HBPTO* 1,738,2001
unreported route
rat 		lowest published toxic dose: 1,575 mg/kg/21 day- continuous Endocrine: Estrogenic

Endocrine: Other changes

Reproductive: Maternal effects: Menstrual cycle changes or disorders 		HBPTO* 1,738,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,441,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,59,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,59,1999
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,87,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 mg/m3 (total dust), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 10 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ATRAZINE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18420;
Number of Industries 1;
Total Number of Facilities 165;
Number of Occupations 2;
Total Number of Employees Exposed 331
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18420;
Number of Industries 1;
Total Number of Facilities 44;
Number of Occupations 9;
Total Number of Employees Exposed 1,001;
Total Number of Female Employees Exposed 123


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100001)
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for season-long weed control in corn, sorghum and certain other crops
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8894
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
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DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
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Used for season-long weed control in corn, sorghum and certain other crops

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 11121-31-6
ALT CAS #: 12040-45-8
ALT CAS #: 12797-72-7
ALT CAS #: 39400-72-1
ALT CAS #: 69771-31-9
ALT CAS #: 93616-39-8
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