The Registry of Toxic Effects of Chemical Substances

s - Triazine, 2 - chloro - 4,6 - bis (isopropylamino) -

RTECS #: XY5300000

CAS #: 139-40-2

UPDATE: November 2004 MW: 229.75 MF: C9H16ClN5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Chloro - 4,6 - bis (isopropylamino) - s - triazine
  2. 6 - Chloro - N,N' - bis (1 - methylethyl) - 1,3,5 - triazine - 2,4 - diamine
  3. 6 - Chloro - N,N' - diisopropyl - 1,3,5 - triazine - 2,4 - diyldiamine
  4. G - 30028
  5. Geigy 30,028
  6. Gesamil
  7. Milogard
  8. Milo - pro
  9. Plantulin
  1. Primatol P
  2. Propasin
  3. Propazin
  4. Propazine
  5. Propazine (herbicide)
  6. 2,4 - Bis (isopropylamino) - 6 - chloro - s - triazine
  7. 2,4 - Bis (propylamino) - 6 - chlor - 1,3,5 - triazin (German)
  8. Prozinex
  9. 1,3,5 - Triazine - 2,4 - diamine, 6 - chloro - N,N' - bis (1 - methylethyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** OTS0535303


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 11 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159
oral
rat 		lowest published toxic dose: 43,800 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** OTS0543186
oral
rat 		lowest published toxic dose: 36.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors 		HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,200 mg/kg N/R 85GMAT -,35,1982
oral
mouse 		lethal dose (50 percent kill): 3,180 mg/kg N/R 85GMAT -,35,1982
oral
rat 		lethal dose (50 percent kill): 3,840 mg/kg N/R 85GMAT -,35,1982
subcutaneous
rat 		lethal dose (50 percent kill): 395 mg/kg N/R FATOAO 42,163,1979
skin
rat 		lethal dose (50 percent kill): >3,100 mg/kg N/R PEMNDP 9,721,1991
skin
rabbit 		lethal dose (50 percent kill): >10,200 mg/kg N/R CIGET* -,-,1977
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 6 gm/kg N/R GISAAA 44(6),81,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 2,250 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 246.37 gm/kg/78 week- continuous Cardiac: Cardiomyopathy including infarction HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 36.5 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 1,493.8 mg/kg/14 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 76,190,2003
oral
rat 		lowest published toxic dose: 2,134 mg/kg/20 day- intermittent Endocrine: Changes in pituitary weight

Reproductive: Maternal effects: Uterus, cervix, vagina 		TOSCF2 76,190,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,146,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a preemergence selective herbicide to control annual broadleaf weeds and grasses
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as a preemergence selective herbicide to control annual broadleaf weeds and grasses

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector

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