The Registry of Toxic Effects of Chemical Substances

s - Triazine, 2 - chloro - 4,6 - bis (ethylamino) -

RTECS #: XY5250000

CAS #: 122-34-9

UPDATE: November 2003 MW: 201.69 MF: C7H12ClN5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. A 2079
  2. Aktinit S
  3. Aquazine
  4. Azotop
  5. Batazine FLO
  6. 2,4 - Bis (aethylamino) - 6 - chlor - 1,3,5 - triazin (German)
  7. CET
  8. 2 - Chloro - 4,6 - bis (ethylamino) - s - triazine
  9. 2 - Chloro - 4,6 - bis (ethylamino) - 1,3,5 - triazine
  10. 6 - Chloro - N,N' - diethyl - 1,3,5 - triazine - 2,4 - diamine
  11. G 27692
  12. Geigy 27,692
  13. Gesatop
  14. Gesatop 50
  15. Premazine
  16. Primatol S
  17. Princep
  18. Printop
  19. Radocon
  20. Radokor
  21. Simanex
  22. Simatsin - neste
  23. Simazin
  24. Simazine
  1. Simazine 80W
  2. Symazine
  3. Tafazine
  4. Tafazine 50 - W
  5. Taphazine
  6. 2,4 - Bis (ethylamino) - 6 - chloro - s - triazine
  7. Bitemol S 50
  8. CAT (herbicide)
  9. CDT
  10. Cekusan
  11. Cekusima
  12. Cekuzina - S
  13. H 1803
  14. Herbatoxol S
  15. Herbazin
  16. Herbazin 50
  17. Herbex (pesticide)
  18. Herboxy
  19. Hungazin DT
  20. Triazine A 384
  21. 1,3,5 - Triazine - 2,4 - diamine, 6 - chloro - N,N' - diethyl - (9CI)
  22. W 6658
  23. Yrodazin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		80 mg moderate CIGET* -,-,1977
skin
rabbit 		500 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
human 		10 ppm/1 year- intermittent MUREAV 537,141,2003
dominant lethal test parenteral
Drosophila melanogaster 		396 µmol/L JTEHD6 3,691,1977
dominant lethal test oral
Drosophila melanogaster 		6,000 ppm JTEHD6 3,691,1977
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L NTIS** PB84-138973
sister chromatid exchange human lymphocyte 1 mg/L BSIBAC 60,2149,1984
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		396 µmol/L JTEHD6 3,691,1977
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		2,000 ppm JPFCD2 15,867,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 17 mg/m3/2 hour (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB277-077
oral
rat 		lowest published toxic dose: 3,120 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		CHYCDW 15,83,1981
oral
rat 		lowest published toxic dose: 780 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system CHYCDW 15,83,1981
oral
rat 		lowest published toxic dose: 25 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CHYCDW 15,83,1981
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NNGADV 15,315,1990
oral
rat 		lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** OTS0535324
oral
rabbit 		lowest published toxic dose: 975 mg/kg (7-19 day pregnant) Reproductive: Other effects on female NNGADV 15,315,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,380 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		NTIS** OTS0543187
oral
rat 		lowest published toxic dose: 36.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors 		HBPTO* 2,1514,2001
subcutaneous
mouse 		lowest published toxic dose: 35 gm/kg/87 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		VOONAW 16(1),82,1970
subcutaneous
rat 		lowest published toxic dose: 16 gm/kg/61 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 16(1),82,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 9,800 mg/m3/4 hour N/R FMCHA2 -,C275,1991
intravenous
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R CSLNX* NX#04003
oral
chicken 		lethal dose (50 percent kill): >5 gm/kg N/R 85JFAN A369,1984
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 2,014 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Skin and Appendages: Other: Hair 		NTIS** PB288-416
oral
mouse 		lowest published lethal dose: 5 gm/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 27(8),22,1962
oral
pigeon 		lethal dose (50 percent kill): >5 gm/kg N/R 85JFAN A369,1984
oral
rat 		lethal dose (50 percent kill): 971 mg/kg N/R FAATDF 7,299,1986
oral
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R 85JFAN A369,1984
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R NNGADV 15,315,1990
skin
rabbit 		lethal dose (50 percent kill): >10,200 mg/kg N/R YKYUA6 37,427,1986
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,400 mg/kg N/R GISAAA 44(6),81,1979
unreported route
rat 		lethal dose (50 percent kill): 1,390 mg/kg N/R GTPZAB 7(5),54,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 4,550 mg/kg/13 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,315,1990
oral
dog 		lowest published toxic dose: 910 mg/kg/52 week- continuous Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,315,1990
oral
dog 		lowest published toxic dose: 12.06 gm/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 79,800 mg/kg/95 week- continuous Behavioral: Food intake (animal)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,315,1990
oral
mouse 		lowest published toxic dose: 72.27 gm/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 43,680 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Blood: Changes in platelet count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 15,315,1990
oral
rat 		lowest published toxic dose: 10 gm/kg/7 week- intermittent Liver: Other changes

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 7(5),54,1963
oral
rat 		lowest published toxic dose: 21,840 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** OTS0555005
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Endocrine: Other changes JTEHD6 43,155,1994
oral
rat 		lowest published toxic dose: 600 mg/kg/2 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Tumorigenic: Cells (cultured) transformed 		JTEHF8 43,183,1994
oral
rat 		lowest published toxic dose: 11.34 gm/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 3,869 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 3,869 mg/kg/2 year- continuous Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,625,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,495,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,495,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,625,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,625,1999
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,148,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4125;
Number of Industries 1;
Total Number of Facilities 29;
Number of Occupations 1;
Total Number of Employees Exposed 173
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4125;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 6;
Total Number of Employees Exposed 356


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an herbicide for non-selective or industrial weed control in nursery stock
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an herbicide for non-selective or industrial weed control in nursery stock

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 11141-20-1
ALT CAS #: 12764-71-5
ALT CAS #: 39291-64-0
ALT CAS #: 119603-94-0
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