The Registry of Toxic Effects of Chemical Substances

p - Toluidine, alpha,alpha,alpha - trifluoro - 2,6 - dinitro - N,N - dipropyl -

RTECS #: XU9275000

CAS #: 1582-09-8

UPDATE: August 2004 MW: 335.32 MF: C13H16F3N3O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Agreflan
  2. Agriflan 24
  3. Benzenamine, 2,6 - dinitro - N,N - dipropyl - 4 - (trifluoromethyl) - (9CI)
  4. Crisalin
  5. Digermin
  6. 2,6 - Dinitro - N,N - dipropyl - 4 - (trifluoromethyl) benzenamine
  7. 2,6 - Dinitro - N,N - di - n - propyl - alpha,alpha,alpha - trifluoro - p - toluidine
  8. 2,6 - Dinitro - 4 - trifluormethyl - N,N - dipropylanilin (German)
  9. 4 - (Di - n - propylamino) - 3,5 - dinitro - 1 - trifluoromethylbenzene
  10. N,N - Dipropyl - 2,6 - dinitro - 4 - trifluormethylanilin (German)
  11. N,N - Dipropyl - 2,6 - dinitro - 4 - trifluoromethylaniline
  12. N,N - Di - n - propyl - 2,6 - dinitro - 4 - trifluoromethylaniline
  13. N,N - Dipropyl - 4 - trifluoromethyl - 2,6 - dinitroaniline
  14. Elancolan
  15. NCI - C00442
  16. Nitran
  17. Nitran K
  18. Olitref
  19. Super - Treflan
  1. Su seguro carpidor
  2. Synfloran
  3. L - 36352
  4. Lilly 36,352
  5. Trefanocide
  6. Treficon
  7. Treflan
  8. Treflanocide elancolan
  9. TRI - 4
  10. Trifloran
  11. alpha,alpha,alpha - Trifluoro - 2,6 - dinitro - N,N - dipropyl - p - toluidine
  12. 4 - (Trifluoromethyl) - 2,6 - dinitro - N,N - dipropylaniline
  13. Trifluralin
  14. Trifluralina 600
  15. Trifluraline
  16. Triflurex
  17. Trikepin
  18. Tristar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 2 ppm PATHAB 73,707,1981
cytogenetic analysis intraperitoneal
mouse 		200 mg/kg EESADV 4,263,1980
dominant lethal test intraperitoneal
mouse 		200 mg/kg EESADV 4,263,1980
DNA damage human lymphocyte 5 mg/L MUREAV 344,41,1995
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
gene conversion and mitotic recombination Aspergillus nidulans 100 µg/plate AISSAW 18,123,1982
sister chromatid exchange hamster ovary 160 µg/L ENMUDM 7,1,1985
sister chromatid exchange human lymphocyte 1 mg/L BSIBAC 60,2149,1984
sex chromosome loss and nondisjunction Neurospora crassa 1 mg/L EVHPAZ 31,75,1979
specific locus test multiple
Drosophila melanogaster 		1,000 ppm EMMUEG 25,148,1995
specific locus test oral
Drosophila melanogaster 		10 mmol/L MUREAV 557,53,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetal death 		EESADV 4,263,1980
oral
mouse 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on newborn: Stillbirth TJADAB 23,33,1981
oral
rat 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTOD7 30,1031,1992
oral
rat 		lowest published toxic dose: 21,800 mg/kg (multigeneration) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FCTOD7 30,1031,1992
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 26,181,1995
oral
rabbit 		lowest published toxic dose: 6,500 mg/kg (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 26,181,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 2,600 µg/kg/39 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		PATHAB 73,707,1981
oral
mouse 		lowest published toxic dose: 180 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NCITR* NCI-TR-34,1978
oral
mouse 		toxic dose : 340 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NCITR* NCI-TR-34,1978
subcutaneous
mouse 		lowest published toxic dose: 2,600 µg/kg/39 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		PATHAB 73,707,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 2,800 mg/m3/1 hour N/R NNGADV 16,557,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,600 mg/kg N/R BECTA6 20,554,1978
oral
chicken 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,851,1991
oral
dog 		lethal dose (50 percent kill): >10 gm/kg Gastrointestinal: Hypermotility, diarrhea FCTOD7 30,1031,1992
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 3,700 mg/kg N/R PCOC** -,1188,1966
oral
mouse 		lethal dose (50 percent kill): 3,197 mg/kg N/R NNGADV 16,557,1991
oral
rat 		lethal dose (50 percent kill): 1,930 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		FCTOD7 30,1031,1992
oral
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,851,1991
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R WRPCA2 9,119,1970
unreported route
mammal (species unspecified) 		lowest published lethal dose: 5 gm/kg N/R 85JCAE -,604,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 193,66,2003
oral
dog 		lowest published toxic dose: 34,216 mg/kg/26 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 30,1031,1992
oral
dog 		lowest published toxic dose: 91,728 mg/kg/1 year- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		FCTOD7 30,1031,1992
oral
dog 		lowest published toxic dose: 27,375 mg/kg/3 year- intermittent Liver: Changes in liver weight NNGADV 16,557,1991
oral
mouse 		lowest published toxic dose: 54,964 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FCTOD7 30,1031,1992
oral
mouse 		lowest published toxic dose: 60,060 mg/kg/1 year- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTOD7 30,1031,1992
oral
mouse 		lowest published toxic dose: 394 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Changes in bladder weight 		NNGADV 16,557,1991
oral
rat 		lowest published toxic dose: 24,570 mg/kg/45 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		KHZDAN 21,253,1978
oral
rat 		lowest published toxic dose: 35,672 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 30,1031,1992
oral
rat 		lowest published toxic dose: 154 gm/kg/2 year- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 30,1031,1992
oral
rat 		lowest published toxic dose: 9,937 mg/kg/26 week- intermittent Liver: Other changes

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count 		KHZDAN 21,253,1978
skin
rabbit 		lowest published toxic dose: 21 gm/kg/21 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count 		NNGADV 16,557,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 53,515,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,515,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,515,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,155,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84719;
Number of Industries 1;
Total Number of Facilities 112;
Number of Occupations 2;
Total Number of Employees Exposed 371


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as a selective preemergence herbicide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-34,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-34,1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AISSAW Annali dell'Istituto Superiore di Sanita. (Istituto Poligrafico e Zecca dello Stato, Piazza Verdi, 10 Rome, Italy) V.1- 1965-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PATHAB Pathologica. (Via Alessandro Volta, 8 Casella Postale 894, 16128 Genoa, Italy) V.1- 1908-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a selective preemergence herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 39300-53-3
ALT CAS #: 52627-52-8
ALT CAS #: 61373-95-3
ALT CAS #: 75635-23-3
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