The Registry of Toxic Effects of Chemical Substances

p - Toluidine, N,N - dimethyl -

RTECS #: XU5803000

CAS #: 99-97-8

UPDATE: May 2004 MW: 135.23 MF: C9H13N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Benzenamine, N,N,4 - trimethyl -
  2. p - (Dimethylamino) toluene
  3. Dimethyl - p - toluidine
  4. Dimetil - p - toluidina (Italian)
  1. N,N - Dimethyl - p - toluidine
  2. p,N,N - Trimethylaniline
  3. N,N,4 - Trimethylaniline


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage intraperitoneal
mouse 		135 mg/kg EMMUEG 21,349,1993
DNA damage oral
rat 		1,082 mg/kg EMMUEG 21,349,1993
DNA damage intraperitoneal
rat 		541 mg/kg EMMUEG 21,349,1993
micronucleus test hamster lung 900 µmol/L EMMUEG 21,349,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,400 mg/m3/4 hour Olfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation 		NTIS** OTS0573706
inhalation
rat 		lethal concentration (50 percent kill): 1,400 mg/m3/4 hour N/R TOXID9 72,146,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 212 mg/kg N/R TOXID9 72,146,2003
oral
mouse 		lowest published toxic dose: 250 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		TOXID9 72,146,2003
oral
rat 		lethal dose (50 percent kill): 1,650 mg/kg N/R TOXID9 72,146,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3033;
Number of Industries 29;
Total Number of Facilities 2,356;
Number of Occupations 19;
Total Number of Employees Exposed 31,063
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3033;
Number of Industries 42;
Total Number of Facilities 2,570;
Number of Occupations 43;
Total Number of Employees Exposed 62,720;
Total Number of Female Employees Exposed 27,118


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the encapsulation of radioactive wastes
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used in the encapsulation of radioactive wastes

RTECS Compound Description:
   Mutagen

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